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Gene: Tyk2 (tyrosine kinase 2) Mus musculus
Symbol: Tyk2
Name: tyrosine kinase 2
Description: Predicted to have growth hormone receptor binding activity; protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Used to study obesity. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TYK2 (tyrosine kinase 2); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; clofibrate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: JTK1; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2
Homo sapiens (human) : TYK2 (tyrosine kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyk2 (tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyk2 (tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TYK2 (tyrosine kinase 2)
Canis lupus familiaris (dog) : TYK2 (tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyk2 (tyrosine kinase 2)
Sus scrofa (pig) : TYK2 (tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : TYK2 (tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Tyk2 (tyrosine kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBImm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tyk2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316193
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.