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Gene: Nfkb2 (nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100) Mus musculus
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Symbol: Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including follicular dendritic cell differentiation; germinal center formation; and spleen development. Localizes to nucleus. Is expressed in several structures, including early conceptus; genitourinary system; musculature; thymus primordium; and trigeminal ganglion. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2); PARTICIPATES IN adenosine signaling pathway; interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA-binding factor KBF2; lyt; NF kappaB2; NF-kappaB2; nuclear factor NF-kappa-B p100 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; p49; p49/p100; p50B; p52
Orthologs:
Homo sapiens (human) : NFKB2 (nuclear factor kappa B subunit 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nfkb2 (nuclear factor kappa B subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfkb2 (nuclear factor kappa B subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NFKB2 (nuclear factor kappa B subunit 2)
Canis lupus familiaris (dog) : NFKB2 (nuclear factor kappa B subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfkb2 (nuclear factor kappa B subunit 2)
Sus scrofa (pig) : NFKB2 (nuclear factor kappa B subunit 2)
Chlorocebus sabaeus (African green monkey) : NFKB2 (nuclear factor kappa B subunit 2)
Heterocephalus glaber (naked mole-rat) : Nfkb2 (nuclear factor kappa B subunit 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1946,304,320 - 46,312,385 (+)EnsemblGRCm38mm10GRCm38
GRCm381946,300,994 - 46,312,400 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371946,379,227 - 46,386,580 (+)NCBIGRCm37mm9NCBIm37
MGSCv361946,358,929 - 46,365,401 (+)NCBImm8
Celera1947,067,972 - 47,075,305 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Nfkb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316231
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.