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Gene: Bub1b (BUB1B, mitotic checkpoint serine/threonine kinase) Mus musculus
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Symbol: Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Description: Predicted to have protein kinase activity. Involved in metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Localizes to the condensed chromosome outer kinetochore and condensed nuclear chromosome kinetochore. Used to study mosaic variegated aneuploidy syndrome 1. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 1. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU045529; BUBR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog, beta; MAD3/BUB1-related protein kinase; MGC36092; mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382118,598,202 - 118,641,592 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372118,423,947 - 118,467,328 (+)NCBIGRCm37mm9NCBIm37
MGSCv362118,289,697 - 118,333,032 (+)NCBImm8
Celera2119,745,153 - 119,796,040 (+)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Bub1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316317
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.