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Gene: Tmem67 (transmembrane protein 67) Mus musculus
Symbol: Tmem67
Name: transmembrane protein 67
CRRD ID: 1316347
Description: Predicted to have filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including animal organ development; cilium assembly; and negative regulation of centrosome duplication. Localizes to MKS complex; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to colocalize with axoneme. Is expressed in diencephalon; hindbrain lateral wall; metanephros; and organ of Corti. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5330408M12Rik; B230117O07; b2b1163.1Clo; b2b1291.1Clo; meckel syndrome type 3 protein homolog; Meckelin; RP23-203A12.5
Homo sapiens (human) : TMEM67 (transmembrane protein 67)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tmem67 (transmembrane protein 67)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmem67 (transmembrane protein 67)
Pan paniscus (bonobo/pygmy chimpanzee) : TMEM67 (transmembrane protein 67)
Canis lupus familiaris (dog) : TMEM67 (transmembrane protein 67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmem67 (transmembrane protein 67)
Sus scrofa (pig) : TMEM67 (transmembrane protein 67)
Chlorocebus sabaeus (African green monkey) : TMEM67 (transmembrane protein 67)
Heterocephalus glaber (naked mole-rat) : Tmem67 (transmembrane protein 67)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39412,039,355 - 12,090,020 (-)NCBI
GRCm38412,039,355 - 12,090,020 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl412,039,355 - 12,090,020 (-)EnsemblGRCm38mm10GRCm38
MGSCv37411,966,502 - 12,015,104 (-)NCBIGRCm37mm9NCBIm37
MGSCv36411,966,792 - 12,015,104 (-)NCBImm8
Celera411,852,088 - 11,951,004 (-)NCBICelera
Cytogenetic Map4A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tmem67
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316347
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.