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Gene: Lias (lipoic acid synthetase) Mus musculus
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Symbol: Lias
Name: lipoic acid synthetase
Description: Exhibits lipoate synthase activity. Involved in several processes, including lipoate biosynthetic process; neural tube closure; and response to lipopolysaccharide. Localizes to mitochondrion. Is expressed in alimentary system; liver; metanephros; salivary gland; and urinary system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase); PARTICIPATES IN lipoic acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900022L22Rik; 4933425M12Rik; 7a5ex; C77512; lip-syn; lipoate synthase; lipoic acid synthase; lipoyl synthase, mitochondrial; LS; MGC7254; mLip1
Orthologs:
Homo sapiens (human) : LIAS (lipoic acid synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lias (lipoic acid synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lias (lipoic acid synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : LIAS (lipoic acid synthetase)
Canis lupus familiaris (dog) : LIAS (lipoic acid synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lias (lipoic acid synthetase)
Sus scrofa (pig) : LIAS (lipoic acid synthetase)
Chlorocebus sabaeus (African green monkey) : LIAS (lipoic acid synthetase)
Heterocephalus glaber (naked mole-rat) : Lias (lipoic acid synthetase)
more info ...
Related Pseudogenes: Gm18127  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl565,391,497 - 65,410,693 (+)EnsemblGRCm38mm10GRCm38
GRCm38565,391,497 - 65,410,423 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37565,782,736 - 65,800,446 (+)NCBIGRCm37mm9NCBIm37
MGSCv36565,670,632 - 65,688,342 (+)NCBImm8
Celera562,668,175 - 62,685,891 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lias
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316365
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.