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Gene: Lias (lipoic acid synthetase) Mus musculus
Symbol: Lias
Name: lipoic acid synthetase
Description: Exhibits lipoate synthase activity. Involved in several processes, including lipoate biosynthetic process; neural tube closure; and response to lipopolysaccharide. Localizes to mitochondrion. Is expressed in alimentary system; liver; metanephros; salivary gland; and urinary system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase); PARTICIPATES IN lipoic acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900022L22Rik; 4933425M12Rik; 7a5ex; C77512; lip-syn; lipoate synthase; lipoic acid synthase; lipoyl synthase, mitochondrial; LS; MGC7254; mLip1
Homo sapiens (human) : LIAS (lipoic acid synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lias (lipoic acid synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lias (lipoic acid synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : LIAS (lipoic acid synthetase)
Canis lupus familiaris (dog) : LIAS (lipoic acid synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lias (lipoic acid synthetase)
Sus scrofa (pig) : LIAS (lipoic acid synthetase)
Chlorocebus sabaeus (African green monkey) : LIAS (lipoic acid synthetase)
Heterocephalus glaber (naked mole-rat) : Lias (lipoic acid synthetase)
more info ...
Related Pseudogenes: Gm18127  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl565,391,497 - 65,410,693 (+)EnsemblGRCm38mm10GRCm38
GRCm38565,391,497 - 65,410,423 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37565,782,736 - 65,800,446 (+)NCBIGRCm37mm9NCBIm37
MGSCv36565,670,632 - 65,688,342 (+)NCBImm8
Celera562,668,175 - 62,685,891 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lias
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316365
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.