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Gene: RPS6KA4 (ribosomal protein S6 kinase A4) Homo sapiens
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Symbol: RPS6KA4
Name: ribosomal protein S6 kinase A4
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Localizes to the cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; MSK2; nuclear mitogen- and stress-activated protein kinase 2; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RSK-B; RSKB; S6K-alpha-4
Orthologs:
Mus musculus (house mouse) : Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6ka4 (ribosomal protein S6 kinase A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6ka4 (ribosomal protein S6 kinase A4)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KA4 (ribosomal protein S6 kinase A4)
Canis lupus familiaris (dog) : RPS6KA4 (ribosomal protein S6 kinase A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6ka4 (ribosomal protein S6 kinase A4)
Sus scrofa (pig) : RPS6KA4 (ribosomal protein S6 kinase A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,359,162 - 64,372,215 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,126,625 - 64,139,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,883,201 - 63,896,263 (+)NCBINCBI36hg18NCBI36
Build 341163,883,200 - 63,896,262NCBI
Celera1161,452,629 - 61,465,691 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,454,630 - 60,467,467 (+)NCBIHuRef
CHM1_11164,009,642 - 64,022,700 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RPS6KA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316377
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.