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Gene: NKX6-2 (NK6 homeobox 2) Homo sapiens
Symbol: NKX6-2
Name: NK6 homeobox 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of myelination; and regulation of transcription, DNA-templated. Predicted to localize to the nuclear chromatin. Implicated in spastic ataxia 8; INTERACTS WITH 17beta-estradiol; butanal; silicon dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glial and testis-specific homeobox protein; GTX; homeobox 6B; homeobox protein NK-6 homolog B; homeobox protein Nkx-6.2; MGC126684; NK homeobox family 6, B; NK6 transcription factor related, locus 2; NKX6.2; NKX6B; SPAX8
Mus musculus (house mouse) : Nkx6-2 (NK6 homeobox 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx6-2 (NK6 homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx6-2 (NK6 homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX6-2 (NK6 homeobox 2)
Canis lupus familiaris (dog) : NKX6-2 (NK6 homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx6-2 (NK6 homeobox 2)
Sus scrofa (pig) : NKX6-2 (NK6 homeobox 2)
Chlorocebus sabaeus (African green monkey) : NKX6-2 (NK6 homeobox 2)
Heterocephalus glaber (naked mole-rat) : Nkx6-2 (NK6 homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10132,783,179 - 132,786,147 (-)EnsemblGRCh38hg38GRCh38
GRCh3810132,782,229 - 132,786,147 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710134,598,320 - 134,599,537 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,448,310 - 134,449,527 (-)NCBINCBI36hg18NCBI36
Build 3410134,448,409 - 134,449,442NCBI
Celera10128,918,129 - 128,919,346 (+)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,149,796 - 128,168,438 (-)NCBIHuRef
CHM1_110134,879,801 - 134,881,014 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX6-2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316381
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.