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Gene: BRD4 (bromodomain containing 4) Homo sapiens
Symbol: BRD4
Name: bromodomain containing 4
Description: Exhibits several functions, including P-TEFb complex binding activity; RNA polymerase II CTD heptapeptide repeat kinase activity; and lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of cell cycle; positive regulation of histone H3-K36 trimethylation; and regulation of transcription, DNA-templated. Localizes to condensed nuclear chromosome and nucleoplasm. Implicated in colon cancer and idiopathic pulmonary fibrosis. Biomarker of melanoma; thyroid gland papillary carcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bromodomain-containing 4; bromodomain-containing protein 4; CAP; chromosome-associated protein; HUNK1; HUNKI; MCAP
Mus musculus (house mouse) : Brd4 (bromodomain containing 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brd4 (bromodomain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brd4 (bromodomain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : BRD4 (bromodomain containing 4)
Canis lupus familiaris (dog) : BRD4 (bromodomain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brd4 (bromodomain containing 4)
Sus scrofa (pig) : BRD4 (bromodomain containing 4)
Chlorocebus sabaeus (African green monkey) : BRD4 (bromodomain containing 4)
Heterocephalus glaber (naked mole-rat) : Brd4 (bromodomain containing 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1915,235,519 - 15,332,545 (-)EnsemblGRCh38hg38GRCh38
GRCh381915,235,519 - 15,332,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371915,348,301 - 15,443,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,209,301 - 15,252,262 (-)NCBINCBI36hg18NCBI36
Build 341915,209,300 - 15,252,262NCBI
Celera1915,243,961 - 15,286,908 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1914,916,406 - 14,959,159 (-)NCBIHuRef
CHM1_11915,347,786 - 15,390,760 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BRD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316385
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.