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Gene: AIM2 (absent in melanoma 2) Homo sapiens
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Symbol: AIM2
Name: absent in melanoma 2
Description: Exhibits double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein-containing complex assembly; and regulation of DNA-binding transcription factor activity. Localizes to AIM2 inflammasome complex; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: interferon-inducible protein AIM2; PYHIN4
Orthologs:
Mus musculus (house mouse) : Aim2 (absent in melanoma 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aim2 (absent in melanoma 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AIM2 (absent in melanoma 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aim2 (absent in melanoma 2)
Chlorocebus sabaeus (African green monkey) : AIM2 (absent in melanoma 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1159,062,484 - 159,147,096 (-)EnsemblGRCh38hg38GRCh38
GRCh381159,059,226 - 159,132,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371159,028,790 - 159,046,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,298,899 - 157,313,271 (-)NCBINCBI36hg18NCBI36
Build 341155,845,347 - 155,859,720NCBI
Celera1132,102,542 - 132,116,908 (-)NCBI
Cytogenetic Map1q23.1-q23.2NCBI
HuRef1130,389,543 - 130,403,802 (-)NCBIHuRef
CHM1_11160,427,707 - 160,442,075 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on AIM2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316387
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.