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Gene: DKK1 (dickkopf WNT signaling pathway inhibitor 1) Homo sapiens
Symbol: DKK1
Name: dickkopf WNT signaling pathway inhibitor 1
Description: Exhibits co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including regulation of cell fate commitment; regulation of gene expression; and regulation of protein phosphorylation. Localizes to the extracellular space and plasma membrane. Implicated in anodontia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dickkopf 1 homolog; dickkopf related protein-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK-1; hDkk-1; SK
Mus musculus (house mouse) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Canis lupus familiaris (dog) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Sus scrofa (pig) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Chlorocebus sabaeus (African green monkey) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1052,314,281 - 52,318,042 (+)EnsemblGRCh38hg38GRCh38
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBINCBI36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DKK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316435
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.