Dkk1 (dickkopf WNT signaling pathway inhibitor 1) - Chinchilla Research Resource Database
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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Mus musculus
Analyze
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
CRRD ID: 1316436
Description: Predicted to have co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including embryonic morphogenesis; negative regulation of signal transduction; and regulation of nervous system development. Predicted to localize to extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dickkopf homolog 1; dickkopf-1; dickkopf-like protein 1; dickkopf-related protein 1; dkk-1; mdkk-1
Orthologs:
Homo sapiens (human) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Canis lupus familiaris (dog) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Sus scrofa (pig) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Chlorocebus sabaeus (African green monkey) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,523,276 - 30,526,896 (-)NCBI
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBImm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ampicillin  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzamides  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
buserelin  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
carbamazepine  (EXP,ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
diclofenac  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethosuximide  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
isobutanol  (ISO)
L-ascorbic acid  (ISO)
lead nitrate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
p-anisidine  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell morphogenesis involved in differentiation  (IMP)
embryonic limb morphogenesis  (IGI)
endoderm development  (IMP)
endoderm formation  (IDA)
face morphogenesis  (IMP)
forebrain development  (IGI)
hair follicle development  (IDA)
head morphogenesis  (IGI)
learning or memory  (IDA)
limb development  (IMP)
mesoderm formation  (IDA)
modulation of age-related behavioral decline  (IDA)
motor learning  (IDA)
multicellular organism development  (IEA)
negative regulation of apoptotic process  (IDA)
negative regulation of BMP signaling pathway  (IDA)
negative regulation of canonical Wnt signaling pathway  (IBA,IDA,IGI,IMP,ISO)
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of neuron projection development  (IDA)
negative regulation of ossification  (IMP)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of presynapse assembly  (IDA)
negative regulation of protein binding  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of Wnt signaling pathway  (IDA,ISO)
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly  (ISO,TAS)
positive regulation of gene expression  (IDA,ISO)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (IDA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of midbrain dopaminergic neuron differentiation  (IMP)
positive regulation of neuron death  (ISO)
positive regulation of tau-protein kinase activity  (IDA)
regulation of endodermal cell fate specification  (ISO)
regulation of receptor internalization  (ISO)
regulation of synapse organization  (IDA)
regulation of synaptic transmission, glutamatergic  (IDA)
regulation of Wnt signaling pathway  (IMP)
response to retinoic acid  (IDA)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (IGI)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior head development  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal head size  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal kidney collecting duct epithelium morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal mandibular prominence morphology  (IAGP)
abnormal presomitic mesoderm morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
absent diencephalon  (IAGP)
absent frontonasal prominence  (IAGP)
absent mandible  (IAGP)
absent maxilla  (IAGP)
absent nasal bone  (IAGP)
absent nasal placodes  (IAGP)
absent optic vesicle  (IAGP)
anophthalmia  (IAGP)
caudal body truncation  (IAGP)
decreased forebrain size  (IAGP)
decreased midbrain size  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine glucose level  (IAGP)
decreased urine phosphate level  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine protein level  (IAGP)
decreased urine sodium level  (IAGP)
ectopic digits  (IAGP)
elongated kidney papilla  (IAGP)
hydronephrosis  (IAGP)
incomplete embryo turning  (IAGP)
incomplete somite formation  (IAGP)
increased bone volume  (IAGP)
increased kidney cell proliferation  (IAGP)
increased urine calcium level  (IAGP)
increased urine chloride ion level  (IAGP)
kinked tail  (IAGP)
microcephaly  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oliguria  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydactyly  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
rostral body truncation  (IAGP)
small interparietal bone  (IAGP)
small parietal bone  (IAGP)
syndactyly  (IAGP)
thick apical ectodermal ridge  (IAGP)
References

Additional References at PubMed
PMID:9450748   PMID:10208746   PMID:10349636   PMID:10495270   PMID:10559490   PMID:11042159   PMID:11076861   PMID:11114168   PMID:11171400   PMID:11217851   PMID:11412024   PMID:11702953  
PMID:11820816   PMID:11867524   PMID:12015971   PMID:12050670   PMID:12194849   PMID:12412008   PMID:12413903   PMID:12477932   PMID:12490556   PMID:12544841   PMID:12588852   PMID:12812787  
PMID:12925589   PMID:12952897   PMID:12972006   PMID:14660441   PMID:14681479   PMID:14695885   PMID:15053977   PMID:15115753   PMID:15143170   PMID:15242796   PMID:15342465   PMID:15358670  
PMID:15527894   PMID:15576404   PMID:15615879   PMID:15617677   PMID:15758175   PMID:15759274   PMID:15857913   PMID:15880404   PMID:15880584   PMID:15907834   PMID:16109169   PMID:16120640  
PMID:16126904   PMID:16141072   PMID:16141073   PMID:16195809   PMID:16207751   PMID:16245025   PMID:16256739   PMID:16263759   PMID:16521043   PMID:16678814   PMID:16682203   PMID:16730481  
PMID:16738056   PMID:16753024   PMID:16763196   PMID:16805831   PMID:16813524   PMID:16829211   PMID:16839541   PMID:16987511   PMID:16989802   PMID:17002498   PMID:17027228   PMID:17064353  
PMID:17068150   PMID:17068196   PMID:17075876   PMID:17095659   PMID:17127040   PMID:17128274   PMID:17133501   PMID:17199045   PMID:17212358   PMID:17237793   PMID:17257418   PMID:17360443  
PMID:17389379   PMID:17397822   PMID:17481602   PMID:17494089   PMID:17507982   PMID:17610272   PMID:17613296   PMID:17669393   PMID:17699607   PMID:17700537   PMID:17804636   PMID:17951031  
PMID:17964517   PMID:17971207   PMID:18038450   PMID:18068158   PMID:18157121   PMID:18157634   PMID:18174290   PMID:18241853   PMID:18242177   PMID:18256193   PMID:18257070   PMID:18287559  
PMID:18294945   PMID:18297060   PMID:18346943   PMID:18351675   PMID:18403408   PMID:18458345   PMID:18462699   PMID:18502762   PMID:18505367   PMID:18505732   PMID:18505822   PMID:18541538  
PMID:18613030   PMID:18653765   PMID:18809738   PMID:18827832   PMID:18927151   PMID:18927154   PMID:18951693   PMID:19016584   PMID:19056886   PMID:19057969   PMID:19141668   PMID:19153222  
PMID:19185060   PMID:19234195   PMID:19334288   PMID:19417213   PMID:19477957   PMID:19501082   PMID:19515997   PMID:19562671   PMID:19605690   PMID:19615442   PMID:19706528   PMID:19737917  
PMID:19776352   PMID:19806668   PMID:19850024   PMID:19850029   PMID:19874086   PMID:19913006   PMID:19936252   PMID:19943155   PMID:20042673   PMID:20050968   PMID:20063381   PMID:20093360  
PMID:20142103   PMID:20144607   PMID:20160075   PMID:20161711   PMID:20211162   PMID:20383322   PMID:20439124   PMID:20445055   PMID:20450902   PMID:20484817   PMID:20510229   PMID:20532162  
PMID:20630950   PMID:20730911   PMID:20847303   PMID:20929859   PMID:20940260   PMID:21087601   PMID:21185284   PMID:21228006   PMID:21248711   PMID:21267068   PMID:21304589   PMID:21307092  
PMID:21347250   PMID:21351149   PMID:21354128   PMID:21384471   PMID:21386911   PMID:21436291   PMID:21440550   PMID:21445260   PMID:21486944   PMID:21490069   PMID:21491542   PMID:21531785  
PMID:21539829   PMID:21540552   PMID:21549111   PMID:21607803   PMID:21614016   PMID:21652651   PMID:21654186   PMID:21677750   PMID:21873635   PMID:21903671   PMID:21911092   PMID:21917600  
PMID:21924256   PMID:21945937   PMID:22007134   PMID:22022411   PMID:22075149   PMID:22158103   PMID:22166339   PMID:22173065   PMID:22358062   PMID:22374979   PMID:22383895   PMID:22399772  
PMID:22406973   PMID:22407773   PMID:22432025   PMID:22459449   PMID:22488261   PMID:22627288   PMID:22863011   PMID:22912414   PMID:23032104   PMID:23085236   PMID:23152495   PMID:23164821  
PMID:23171658   PMID:23293290   PMID:23302695   PMID:23303816   PMID:23349620   PMID:23390542   PMID:23395445   PMID:23431057   PMID:23469192   PMID:23633963   PMID:23636253   PMID:23651855  
PMID:23685555   PMID:24006258   PMID:24091497   PMID:24139798   PMID:24161570   PMID:24302887   PMID:24447645   PMID:24460718   PMID:24479159   PMID:24496627   PMID:24520934   PMID:24523460  
PMID:24528599   PMID:24618599   PMID:24747916   PMID:24750467   PMID:24819581   PMID:24848709   PMID:24859004   PMID:24952961   PMID:25080367   PMID:25082703   PMID:25231759   PMID:25318560  
PMID:25329657   PMID:25536399   PMID:25545010   PMID:25603465   PMID:25645944   PMID:25664857   PMID:25808845   PMID:25873176   PMID:25910078   PMID:25910836   PMID:25977363   PMID:26206087  
PMID:26218891   PMID:26283362   PMID:26288816   PMID:26351298   PMID:26407640   PMID:26424886   PMID:26450967   PMID:26485363   PMID:26607269   PMID:26648540   PMID:26674341   PMID:26744331  
PMID:26872695   PMID:26934381   PMID:26968737   PMID:26989192   PMID:27026076   PMID:27045006   PMID:27046536   PMID:27393149   PMID:27445154   PMID:27460630   PMID:27521049   PMID:27671872  
PMID:27760115   PMID:27864382   PMID:27913639   PMID:27918563   PMID:28009287   PMID:28069742   PMID:28155238   PMID:28177772   PMID:28324176   PMID:28346476   PMID:28556921   PMID:28760814  
PMID:28813421   PMID:28839193   PMID:28892080   PMID:28893947   PMID:28893950   PMID:29105022   PMID:29168693   PMID:29437780   PMID:29509905   PMID:29643768   PMID:29704238   PMID:29734465  
PMID:29845410   PMID:29875318   PMID:30216540   PMID:30509557   PMID:30575941   PMID:30595533   PMID:30689850   PMID:30735122   PMID:30779862   PMID:30890376   PMID:30953627   PMID:31081743  
PMID:31202927   PMID:31308417   PMID:31371508   PMID:31521827   PMID:31611558   PMID:31649032   PMID:32243674   PMID:32325033   PMID:32439762  


Genomics

Comparative Map Data
Dkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,523,276 - 30,526,896 (-)NCBI
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBImm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
DKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1052,314,281 - 52,318,042 (+)EnsemblGRCh38hg38GRCh38
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBINCBI36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
Dkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
Dkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
DKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,084,963 - 51,088,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,084,027 - 51,089,776 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01048,950,704 - 48,953,815 (+)NCBI
DKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2635,697,618 - 35,701,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12635,697,428 - 35,701,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936787307,290 - 309,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,487,226 - 97,490,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,487,854 - 97,490,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,115,155 - 106,117,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl978,835,162 - 78,840,146 (-)Ensembl
ChlSab1.1978,836,803 - 78,840,158 (-)NCBI
Dkk1
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371930,621,050 - 30,621,258UniSTSGRCm37
MGSCv371930,622,176 - 30,623,423UniSTSGRCm37
MGSCv371930,620,736 - 30,621,258UniSTSGRCm37
MGSCv371930,622,212 - 30,623,214UniSTSGRCm37
MGSCv371930,621,855 - 30,621,916UniSTSGRCm37
MGSCv371930,621,813 - 30,622,166UniSTSGRCm37
MGSCv371930,621,687 - 30,622,166UniSTSGRCm37
Celera1931,331,741 - 31,332,220UniSTS
Celera1931,332,230 - 31,333,477UniSTS
Celera1931,331,867 - 31,332,220UniSTS
Celera1931,332,266 - 31,333,268UniSTS
Celera1931,331,118 - 31,331,312UniSTS
Celera1931,330,804 - 31,331,312UniSTS
Celera1931,331,909 - 31,331,970UniSTS
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,546,560 - 30,546,768UniSTSGRCm38
MGSCv371930,621,050 - 30,621,258UniSTSGRCm37
Celera1931,331,118 - 31,331,312UniSTS
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,546,246 - 30,546,768UniSTSGRCm38
MGSCv371930,620,736 - 30,621,258UniSTSGRCm37
Celera1931,330,804 - 31,331,312UniSTS
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,547,197 - 30,547,676UniSTSGRCm38
MGSCv371930,621,687 - 30,622,166UniSTSGRCm37
Celera1931,331,741 - 31,332,220UniSTS
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,547,686 - 30,548,933UniSTSGRCm38
MGSCv371930,622,176 - 30,623,423UniSTSGRCm37
Celera1931,332,230 - 31,333,477UniSTS
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,547,323 - 30,547,676UniSTSGRCm38
MGSCv371930,621,813 - 30,622,166UniSTSGRCm37
Celera1931,331,867 - 31,332,220UniSTS
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,547,365 - 30,547,426UniSTSGRCm38
MGSCv371930,621,855 - 30,621,916UniSTSGRCm37
Celera1931,331,909 - 31,331,970UniSTS
Cytogenetic Map19C2UniSTS
Dkk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,547,722 - 30,548,724UniSTSGRCm38
MGSCv371930,622,212 - 30,623,214UniSTSGRCm37
Celera1931,332,266 - 31,333,268UniSTS
Cytogenetic Map19C2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192200672732935319Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192779458535317981Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse
4141562Pas3b_mpulmonary adenoma susceptibility 3b (mouse)Not determined2977296261431566Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193015278561431566Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193015279261431566Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193015279261431566Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir291ammu-miR-291a-3pMirecordsexternal_info{changed}NA19628328
Mir292mmu-miR-292-3pMirecordsexternal_info{changed}NA19628328
Mir294mmu-miR-294-3pMirecordsexternal_info{changed}NA19628328
Mir31mmu-miR-31-5pOncomiRDBexternal_infoNANA21048943
Mir295mmu-miR-295-3pMirecordsexternal_info{changed}NA19628328
Mir293mmu-miR-293-5pMirecordsexternal_info{changed}NA19628328

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:270
Interacting mature miRNAs:330
Transcripts:ENSMUST00000025803
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025803   ⟹   ENSMUSP00000025803
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)Ensembl
RefSeq Acc Id: NM_010051   ⟹   NP_034181
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,523,276 - 30,526,896 (-)NCBI
GRCm381930,545,876 - 30,549,496 (-)ENTREZGENE
MGSCv371930,620,366 - 30,623,986 (-)RGD
Celera1931,330,434 - 31,334,040 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034181   ⟸   NM_010051
- Peptide Label: precursor
- UniProtKB: O54908 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025803   ⟸   ENSMUST00000025803

Promoters
RGD ID:13679250
Promoter ID:EPDNEW_M23774
Type:single initiation site
Name:Dkk1_1
Description:Mus musculus dickkopf WNT signaling pathway inhibitor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381930,549,519 - 30,549,579EPDNEW
RGD ID:6829963
Promoter ID:MM_KWN:26826
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000048273
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,623,576 - 30,624,076 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1329040 AgrOrtholog
Ensembl Genes ENSMUSG00000024868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025803 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025803 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Dickkopf_N UniProtKB/Swiss-Prot
  DKK-like UniProtKB/Swiss-Prot
KEGG Report mmu:13380 UniProtKB/Swiss-Prot
MGD MGI:1329040 ENTREZGENE
NCBI Gene 13380 ENTREZGENE
PANTHER PTHR12113 UniProtKB/Swiss-Prot
Pfam Dickkopf_N UniProtKB/Swiss-Prot
PhenoGen Dkk1 PhenoGen
UniGene Mm.214717 ENTREZGENE
UniProt DKK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q80UL5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Dkk1  dickkopf WNT signaling pathway inhibitor 1    dickkopf homolog 1 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.