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Gene: SERPINC1 (serpin family C member 1) Homo sapiens
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Symbol: SERPINC1
Name: serpin family C member 1
Description: Exhibits identical protein binding activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Localizes to the extracellular space. Implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Biomarker of acute kidney failure; nephrotic syndrome; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antithrombin III; antithrombin III isoform; antithrombin-III; AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; MGC22579; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serine-cysteine proteinase inhibitor clade C member 1; serpin C1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; THPH7
Orthologs:
Mus musculus (house mouse) : Serpinc1 (serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Serpinc1 (serpin family C member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpinc1 (serpin family C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINC1 (serpin family C member 1)
Canis lupus familiaris (dog) : SERPINC1 (serpin family C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpinc1 (serpin family C member 1)
Sus scrofa (pig) : SERPINC1 (serpin family C member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1173,903,804 - 173,917,378 (-)Ensembl
GRCh381173,903,519 - 173,917,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371173,872,938 - 173,886,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,139,565 - 172,153,096 (-)NCBINCBI36hg18NCBI36
Build 341170,604,599 - 170,618,130NCBI
Celera1146,982,409 - 146,995,977 (-)NCBI
Cytogenetic Map1q25.1NCBI
HuRef1145,098,064 - 145,111,634 (-)NCBIHuRef
CHM1_11175,295,382 - 175,308,956 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SERPINC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316583
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.