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Gene: SET (SET nuclear proto-oncogene) Homo sapiens
Symbol: SET
Name: SET nuclear proto-oncogene
Description: Predicted to have histone binding activity and protein phosphatase inhibitor activity. Involved in negative regulation of neuron apoptotic process and negative regulation of transcription, DNA-templated. Localizes to several cellular components, including the endoplasmic reticulum; lipid droplet; and perinuclear region of cytoplasm. Implicated in autosomal dominant non-syndromic intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2PP2A; chromatin remodelling factor; HLA-DR-associated protein II; I-2PP2A; I2PP2A; IGAAD; inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; IPP2A2; MRD58; PHAPII; phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; SET nuclear oncogene; SET translocation (myeloid leukemia-associated); TAF-I; TAF-IBETA; template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Mus musculus (house mouse) : Set (SET nuclear oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Set (SET nuclear proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Set (SET nuclear proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : SET (SET nuclear proto-oncogene)
Canis lupus familiaris (dog) : SET (SET nuclear proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Set (SET nuclear proto-oncogene)
Sus scrofa (pig) : SET (SET nuclear proto-oncogene)
more info ...
Related Pseudogenes: SETP1   SETP10   SETP11   SETP12   SETP14   SETP15   SETP16   SETP17   SETP2   SETP20   SETP21   SETP22   SETP3   SETP4   SETP5   SETP6   SETP7   SETP8   SETP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389128,683,432 - 128,696,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,445,934 - 131,458,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,491,682 - 130,498,488 (+)NCBINCBI36hg18NCBI36
Build 349128,531,414 - 128,538,221NCBI
Celera9102,096,741 - 102,109,482 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9101,055,484 - 101,068,248 (+)NCBIHuRef
CHM1_19131,596,913 - 131,609,662 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SET
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316679
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.