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Gene: SET (SET nuclear proto-oncogene) Homo sapiens
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Symbol: SET
Name: SET nuclear proto-oncogene
Description: Predicted to have histone binding activity and protein phosphatase inhibitor activity. Involved in negative regulation of neuron apoptotic process and negative regulation of transcription, DNA-templated. Localizes to several cellular components, including the endoplasmic reticulum; lipid droplet; and perinuclear region of cytoplasm. Implicated in autosomal dominant non-syndromic intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2PP2A; chromatin remodelling factor; HLA-DR-associated protein II; I-2PP2A; I2PP2A; IGAAD; inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; IPP2A2; MRD58; PHAPII; phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; SET nuclear oncogene; SET translocation (myeloid leukemia-associated); TAF-I; TAF-IBETA; template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Orthologs:
Mus musculus (house mouse) : Set (SET nuclear oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Set (SET nuclear proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Set (SET nuclear proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : SET (SET nuclear proto-oncogene)
Canis lupus familiaris (dog) : SET (SET nuclear proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Set (SET nuclear proto-oncogene)
Sus scrofa (pig) : SET (SET nuclear proto-oncogene)
more info ...
Related Pseudogenes: SETP1   SETP10   SETP11   SETP12   SETP14   SETP15   SETP16   SETP17   SETP2   SETP20   SETP21   SETP22   SETP3   SETP4   SETP5   SETP6   SETP7   SETP8   SETP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,683,432 - 128,696,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,445,934 - 131,458,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,491,682 - 130,498,488 (+)NCBINCBI36hg18NCBI36
Build 349128,531,414 - 128,538,221NCBI
Celera9102,096,741 - 102,109,482 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9101,055,484 - 101,068,248 (+)NCBIHuRef
CHM1_19131,596,913 - 131,609,662 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SET
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316679
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.