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Gene: SMC5 (structural maintenance of chromosomes 5) Homo sapiens
Symbol: SMC5
Name: structural maintenance of chromosomes 5
Description: Predicted to have ATP binding activity. Involved in DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Localizes to the cell junction; chromosome; and nuclear body; INTERACTS WITH aflatoxin M1; all-trans-retinoic acid; arsenous acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hSMC5; KIAA0594; SMC protein 5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; smc5 structural maintenance of chromosomes 5-like 1 (yeast); SMC5L1; structural maintenance of chromosomes protein 5
Mus musculus (house mouse) : Smc5 (structural maintenance of chromosomes 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smc5 (structural maintenance of chromosomes 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smc5 (structural maintenance of chromosomes 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SMC5 (structural maintenance of chromosomes 5)
Canis lupus familiaris (dog) : SMC5 (structural maintenance of chromosomes 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smc5 (structural maintenance of chromosomes 5)
Sus scrofa (pig) : SMC5 (structural maintenance of chromosomes 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38970,258,962 - 70,354,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37972,873,878 - 72,969,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36972,063,698 - 72,159,609 (+)NCBINCBI36hg18NCBI36
Build 34970,103,458 - 70,196,886NCBI
Celera943,464,262 - 43,560,152 (+)NCBI
Cytogenetic Map9q21.12NCBI
HuRef942,713,635 - 42,809,515 (+)NCBIHuRef
CHM1_1973,020,407 - 73,116,329 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316718
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.