Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MAD2L2 (mitotic arrest deficient 2 like 2) Homo sapiens
Symbol: MAD2L2
Name: mitotic arrest deficient 2 like 2
Description: Exhibits JUN kinase binding activity and RNA polymerase II activating transcription factor binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by cadherin; regulation of nucleobase-containing compound metabolic process; and regulation of protein metabolic process. Localizes to several cellular components, including the nucleolus; spindle; and zeta DNA polymerase complex. Colocalizes with the anaphase-promoting complex. Implicated in Fanconi anemia complementation group V.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FANCV; hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2 mitotic arrest deficient-like 2; MAD2 mitotic arrest deficient-like 2 (yeast); MAD2-like protein 2; MAD2B; mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; POLZ2; REV7; REV7 homolog
Mus musculus (house mouse) : Mad2l2 (MAD2 mitotic arrest deficient-like 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mad2l2 (mitotic arrest deficient 2 like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mad2l2 (mitotic arrest deficient 2 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MAD2L2 (mitotic arrest deficient 2 like 2)
Canis lupus familiaris (dog) : MAD2L2 (mitotic arrest deficient 2 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mad2l2 (mitotic arrest deficient 2 like 2)
Sus scrofa (pig) : MAD2L2 (mitotic arrest deficient 2 like 2)
Chlorocebus sabaeus (green monkey) : MAD2L2 (mitotic arrest deficient 2 like 2)
Heterocephalus glaber (naked mole-rat) : Mad2l2 (mitotic arrest deficient 2 like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,674,480 - 11,691,650 (-)Ensembl
GRCh38111,674,480 - 11,691,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,734,537 - 11,751,678 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,657,124 - 11,663,780 (-)NCBINCBI36hg18NCBI36
Build 34111,668,802 - 11,675,459NCBI
Celera110,846,601 - 10,863,739 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,888,642 - 10,905,769 (-)NCBIHuRef
CHM1_1111,722,539 - 11,739,685 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MAD2L2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316729
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.