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Gene: Hic1 (hypermethylated in cancer 1) Mus musculus
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Symbol: Hic1
Name: hypermethylated in cancer 1
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Localizes to chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408311; HIC-; HIC-1; hypermethylated in cancer 1 protein
Orthologs:
Homo sapiens (human) : HIC1 (HIC ZBTB transcriptional repressor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hic1 (HIC ZBTB transcriptional repressor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hic1 (HIC ZBTB transcriptional repressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HIC1 (HIC ZBTB transcriptional repressor 1)
Canis lupus familiaris (dog) : HIC1 (HIC ZBTB transcriptional repressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hic1 (HIC ZBTB transcriptional repressor 1)
Sus scrofa (pig) : HIC1 (HIC ZBTB transcriptional repressor 1)
Chlorocebus sabaeus (African green monkey) : HIC1 (HIC ZBTB transcriptional repressor 1)
Heterocephalus glaber (naked mole-rat) : Hic1 (HIC ZBTB transcriptional repressor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)EnsemblGRCm38mm10GRCm38
GRCm381175,161,377 - 75,170,255 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371174,978,067 - 74,983,757 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,980,763 - 74,985,714 (-)NCBImm8
Celera1182,671,336 - 82,677,017 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hic1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316775
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.