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Gene: Hic1 (hypermethylated in cancer 1) Mus musculus
Symbol: Hic1
Name: hypermethylated in cancer 1
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Localizes to chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408311; HIC-; HIC-1; hypermethylated in cancer 1 protein
Homo sapiens (human) : HIC1 (HIC ZBTB transcriptional repressor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hic1 (HIC ZBTB transcriptional repressor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hic1 (HIC ZBTB transcriptional repressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HIC1 (HIC ZBTB transcriptional repressor 1)
Canis lupus familiaris (dog) : HIC1 (HIC ZBTB transcriptional repressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hic1 (HIC ZBTB transcriptional repressor 1)
Sus scrofa (pig) : HIC1 (HIC ZBTB transcriptional repressor 1)
Chlorocebus sabaeus (African green monkey) : HIC1 (HIC ZBTB transcriptional repressor 1)
Heterocephalus glaber (naked mole-rat) : Hic1 (HIC ZBTB transcriptional repressor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)EnsemblGRCm38mm10GRCm38
GRCm381175,161,377 - 75,170,255 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371174,978,067 - 74,983,757 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,980,763 - 74,985,714 (-)NCBImm8
Celera1182,671,336 - 82,677,017 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hic1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316775
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.