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Gene: KDM4C (lysine demethylase 4C) Homo sapiens
Symbol: KDM4C
Name: lysine demethylase 4C
Description: Exhibits several functions, including androgen receptor binding activity; histone demethylase activity; and zinc ion binding activity. Involved in histone lysine demethylation; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Localizes to the nuclear chromatin. Implicated in several diseases, including autistic disorder; esophagus squamous cell carcinoma; head and neck cancer; renal cell carcinoma; and withdrawal disorder. Biomarker of alopecia areata; esophagus squamous cell carcinoma; medulloblastoma; prostate cancer; and stomach carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA146B14.1; FLJ25949; GASC-1 protein; GASC1; gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; jumonji domain containing 2C; jumonji domain-containing protein 2C; KIAA0780; lysine (K)-specific demethylase 4C; lysine-specific demethylase 4C; TDRD14C; tudor domain containing 14C
Mus musculus (house mouse) : Kdm4c (lysine (K)-specific demethylase 4C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm4c (lysine demethylase 4C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4c (lysine demethylase 4C)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4C (lysine demethylase 4C)
Canis lupus familiaris (dog) : KDM4C (lysine demethylase 4C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4c (lysine demethylase 4C)
Sus scrofa (pig) : KDM4C (lysine demethylase 4C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3896,720,863 - 7,175,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3796,720,863 - 7,175,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,747,654 - 7,165,648 (+)NCBINCBI36hg18NCBI36
Build 3496,748,082 - 7,165,647NCBI
Celera96,649,815 - 7,106,122 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef96,675,237 - 7,130,973 (+)NCBIHuRef
CHM1_196,721,531 - 7,175,696 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM4C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316776
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.