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Gene: Lrp1 (low density lipoprotein receptor-related protein 1) Mus musculus
Symbol: Lrp1
Name: low density lipoprotein receptor-related protein 1
Description: Exhibits calcium ion binding activity and cargo receptor activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; circulatory system development; and negative regulation of signal transduction. Localizes to the integral component of plasma membrane. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; myocardial infarction; and sciatic neuropathy. Is expressed in several structures, including brain; extraembryonic component; face; genitourinary system; and intestine. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2mr; AI316852; alpha 2-macroglobulin receptor; alpha-2-macroglobulin receptor; b2b1554Clo; CD91; lipoprotein receptor-related protein; Lrp; LRP-1; prolow-density lipoprotein receptor-related protein 1
Homo sapiens (human) : LRP1 (LDL receptor related protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrp1 (LDL receptor related protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp1 (LDL receptor related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP1 (LDL receptor related protein 1)
Canis lupus familiaris (dog) : LRP1 (LDL receptor related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp1 (LDL receptor related protein 1)
Sus scrofa (pig) : LRP1 (LDL receptor related protein 1)
Chlorocebus sabaeus (African green monkey) : LRP1 (LDL receptor related protein 1)
Heterocephalus glaber (naked mole-rat) : Lrp1 (LDL receptor related protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl10127,538,161 - 127,621,148 (-)Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBImm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316787
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.