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Gene: Lrp1 (low density lipoprotein receptor-related protein 1) Mus musculus
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Symbol: Lrp1
Name: low density lipoprotein receptor-related protein 1
Description: Exhibits calcium ion binding activity and cargo receptor activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; circulatory system development; and negative regulation of signal transduction. Localizes to the integral component of plasma membrane. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; myocardial infarction; and sciatic neuropathy. Is expressed in several structures, including brain; extraembryonic component; face; genitourinary system; and intestine. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2mr; AI316852; alpha 2-macroglobulin receptor; alpha-2-macroglobulin receptor; b2b1554Clo; CD91; lipoprotein receptor-related protein; Lrp; LRP-1; prolow-density lipoprotein receptor-related protein 1
Orthologs:
Homo sapiens (human) : LRP1 (LDL receptor related protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrp1 (LDL receptor related protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp1 (LDL receptor related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP1 (LDL receptor related protein 1)
Canis lupus familiaris (dog) : LRP1 (LDL receptor related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp1 (LDL receptor related protein 1)
Sus scrofa (pig) : LRP1 (LDL receptor related protein 1)
Chlorocebus sabaeus (African green monkey) : LRP1 (LDL receptor related protein 1)
Heterocephalus glaber (naked mole-rat) : Lrp1 (LDL receptor related protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl10127,538,161 - 127,621,148 (-)Ensembl
GRCm3810127,538,157 - 127,621,148 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,975,213 - 127,058,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,941,137 - 127,024,078 (-)NCBImm8
Celera10129,930,007 - 130,012,542 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lrp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316787
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.