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Gene: FOXE3 (forkhead box E3) Homo sapiens
Symbol: FOXE3
Name: forkhead box E3
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including mRNA transcription by RNA polymerase II; negative regulation of cell cycle arrest; and positive regulation of lens epithelial cell proliferation. Localizes to nucleus and transcription factor complex. Implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT11; ASGD2; ASMD; CTRCT34; FKHL12; forkhead box protein E3; forkhead, drosophila, homolog-like 12; forkhead-related protein FKHL12; forkhead-related transcription factor 8; FREAC-8; FREAC8
Mus musculus (house mouse) : Foxe3 (forkhead box E3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxe3 (forkhead box E3)  Alliance
Canis lupus familiaris (dog) : FOXE3 (forkhead box E3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxe3 (forkhead box E3)
Sus scrofa (pig) : FOXE3 (forkhead box E3)
Chlorocebus sabaeus (African green monkey) : FOXE3 (forkhead box E3)
Heterocephalus glaber (naked mole-rat) : Foxe3 (forkhead box E3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl147,416,285 - 47,418,052 (+)EnsemblGRCh38hg38GRCh38
GRCh38147,416,285 - 47,418,052 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37147,881,744 - 47,883,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,654,331 - 47,656,311 (+)NCBINCBI36hg18NCBI36
Build 34147,593,763 - 47,595,743NCBI
Celera146,168,009 - 46,170,038 (+)NCBI
Cytogenetic Map1p33NCBI
HuRef145,998,176 - 46,000,072 (+)NCBIHuRef
CHM1_1147,998,586 - 48,000,566 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FOXE3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316815
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.