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Gene: Fech (ferrochelatase) Mus musculus
Symbol: Fech
Name: ferrochelatase
Description: Exhibits several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Involved in several processes, including porphyrin-containing compound metabolic process; regulation of cellular macromolecule biosynthetic process; and very-low-density lipoprotein particle assembly. Localizes to the mitochondrion. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Orthologous to human FECH (ferrochelatase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine; 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI894116; fch; Fcl; ferrochelatase, mitochondrial; heme synthase; heme synthetase; protoheme ferro-lyase
Homo sapiens (human) : FECH (ferrochelatase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fech (ferrochelatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fech (ferrochelatase)
Pan paniscus (bonobo/pygmy chimpanzee) : FECH (ferrochelatase)
Canis lupus familiaris (dog) : FECH (ferrochelatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fech (ferrochelatase)
Sus scrofa (pig) : FECH (ferrochelatase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381864,456,542 - 64,489,098 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371864,616,204 - 64,648,720 (-)NCBIGRCm37mm9NCBIm37
MGSCv361864,581,919 - 64,614,435 (-)NCBImm8
Celera1865,723,518 - 65,755,460 (-)NCBICelera
Cytogenetic Map18 E1NCBI
cM Map1837.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fech
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316820
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.