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Gene: HDAC4 (histone deacetylase 4) Homo sapiens
Symbol: HDAC4
Name: histone deacetylase 4
Description: Exhibits several functions, including histone deacetylase binding activity; metal ion binding activity; and transcription factor binding activity. Contributes to sequence-specific DNA binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including positive regulation of protein sumoylation; protein deacetylation; and regulation of transcription, DNA-templated. Localizes to the cytosol; nucleoplasm; and transcriptional repressor complex. Implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Biomarker of several diseases, including artery disease (multiple); impotence; neurodegenerative disease (multiple); obesity; and precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AHO3; BDMR; brachydactyly-mental retardation syndrome; HA6116; HD4; HDAC-4; HDAC-A; HDACA; histone deacetylase A; KIAA0288
Mus musculus (house mouse) : Hdac4 (histone deacetylase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac4 (histone deacetylase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac4 (histone deacetylase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC4 (histone deacetylase 4)
Canis lupus familiaris (dog) : HDAC4 (histone deacetylase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac4 (histone deacetylase 4)
Sus scrofa (pig) : HDAC4 (histone deacetylase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382239,048,168 - 239,401,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,969,864 - 240,323,346 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,634,801 - 239,987,580 (-)NCBINCBI36hg18NCBI36
Build 342239,706,635 - 240,058,897NCBI
Celera2233,665,663 - 234,017,808 (-)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2231,741,321 - 232,092,211 (-)NCBIHuRef
CHM1_12239,975,706 - 240,328,679 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HDAC4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316832
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.