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Gene: RAC2 (Rac family small GTPase 2) Homo sapiens
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Symbol: RAC2
Name: Rac family small GTPase 2
Description: This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EN-7; Gx; HSPC022; p21-Rac2; ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac2; small G protein
Orthologs:
Mus musculus (house mouse) : Rac2 (Rac family small GTPase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rac2 (Rac family small GTPase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rac2 (Rac family small GTPase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAC2 (Rac family small GTPase 2)
Canis lupus familiaris (dog) : RAC2 (Rac family small GTPase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rac2 (Rac family small GTPase 2)
Sus scrofa (pig) : RAC2 (Rac family small GTPase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,225,261 - 37,244,299 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,621,301 - 37,640,339 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,951,256 - 35,970,251 (-)NCBINCBI36hg18NCBI36
Build 342235,945,811 - 35,964,805NCBI
Celera2221,422,402 - 21,441,189 (-)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2220,586,313 - 20,605,449 (-)NCBIHuRef
CHM1_12237,580,533 - 37,599,298 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RAC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316839
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.