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Gene: KDM6B (lysine demethylase 6B) Homo sapiens
Symbol: KDM6B
Name: lysine demethylase 6B
CRRD ID: 1316934
Description: Exhibits histone demethylase activity (H3-K27 specific). Involved in histone H3-K27 demethylation. Predicted to localize to MLL3/4 complex and nuclear chromatin. Biomarker of breast carcinoma and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-trimethyl-L-lysine(27) demethylase 6B; jmjC domain-containing protein 3; JMJD3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing protein 3; KIAA0346; lysine (K)-specific demethylase 6B; lysine-specific demethylase 6B; NEDCFSA
Mus musculus (house mouse) : Kdm6b (KDM1 lysine (K)-specific demethylase 6B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm6b (lysine demethylase 6B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm6b (lysine demethylase 6B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM6B (lysine demethylase 6B)
Canis lupus familiaris (dog) : KDM6B (lysine demethylase 6B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm6b (lysine demethylase 6B)
Sus scrofa (pig) : KDM6B (lysine demethylase 6B)
Chlorocebus sabaeus (African green monkey) : KDM6B (lysine demethylase 6B)
Heterocephalus glaber (naked mole-rat) : Kdm6b (lysine demethylase 6B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl177,839,904 - 7,854,796 (+)EnsemblGRCh38hg38GRCh38
GRCh38177,834,210 - 7,854,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,737,521 - 7,758,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,683,960 - 7,698,843 (+)NCBINCBI36hg18NCBI36
Celera177,771,102 - 7,785,939 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,637,994 - 7,652,831 (+)NCBIHuRef
CHM1_1177,752,263 - 7,767,093 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM6B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316934
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.