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Gene: PAPPA (pappalysin 1) Homo sapiens
Symbol: PAPPA
Name: pappalysin 1
Description: Exhibits metallopeptidase activity. Predicted to be involved in cellular protein metabolic process. Localizes to the extracellular region. Implicated in myocardial infarction. Biomarker of artery disease (multiple); degenerative disc disease; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGF-dependent IGFBP-4 protease; IGFBP-4ase; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPA; PAPP-A; PAPPA1; pappalysin-1; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1
Mus musculus (house mouse) : Pappa (pregnancy-associated plasma protein A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pappa1 (pappalysin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pappa (pappalysin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PAPPA (pappalysin 1)
Canis lupus familiaris (dog) : PAPPA (pappalysin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pappa (pappalysin 1)
Sus scrofa (pig) : PAPPA (pappalysin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389116,153,752 - 116,402,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379118,916,071 - 119,164,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369117,955,892 - 118,204,421 (+)NCBINCBI36hg18NCBI36
Build 349115,995,624 - 116,244,153NCBI
Celera989,563,743 - 89,812,291 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef988,522,043 - 88,770,156 (+)NCBIHuRef
CHM1_19119,062,528 - 119,311,011 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PAPPA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317112
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.