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Gene: PAPPA (pappalysin 1) Homo sapiens
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Symbol: PAPPA
Name: pappalysin 1
Description: Exhibits metallopeptidase activity. Predicted to be involved in cellular protein metabolic process. Localizes to the extracellular region. Implicated in myocardial infarction. Biomarker of artery disease (multiple); degenerative disc disease; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGF-dependent IGFBP-4 protease; IGFBP-4ase; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPA; PAPP-A; PAPPA1; pappalysin-1; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1
Orthologs:
Mus musculus (house mouse) : Pappa (pregnancy-associated plasma protein A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pappa1 (pappalysin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pappa (pappalysin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PAPPA (pappalysin 1)
Canis lupus familiaris (dog) : PAPPA (pappalysin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pappa (pappalysin 1)
Sus scrofa (pig) : PAPPA (pappalysin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389116,153,752 - 116,402,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379118,916,071 - 119,164,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369117,955,892 - 118,204,421 (+)NCBINCBI36hg18NCBI36
Build 349115,995,624 - 116,244,153NCBI
Celera989,563,743 - 89,812,291 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef988,522,043 - 88,770,156 (+)NCBIHuRef
CHM1_19119,062,528 - 119,311,011 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PAPPA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317112
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.