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Gene: BAG3 (BAG cochaperone 3) Homo sapiens
Symbol: BAG3
Name: BAG cochaperone 3
Description: Exhibits adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of aggrephagy; and positive regulation of nucleocytoplasmic transport. Localizes to several cellular components, including chaperone complex; cytosol; and nucleus. Implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Biomarker of pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BAG family molecular chaperone regulator 3; BAG-3; BAG-family molecular chaperone regulator-3; bcl-2-associated athanogene 3; bcl-2-binding protein Bis; BCL2 associated athanogene 3; BCL2-associated athanogene 3; BCL2-binding athanogene 3; BIS; CAIR-1; docking protein CAIR-1; MFM6; MGC104307
Mus musculus (house mouse) : Bag3 (BCL2-associated athanogene 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bag3 (BAG cochaperone 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bag3 (BAG cochaperone 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BAG3 (BAG cochaperone 3)
Canis lupus familiaris (dog) : BAG3 (BAG cochaperone 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bag3 (BAG cochaperone 3)
Sus scrofa (pig) : BAG3 (BAG cochaperone 3)
Chlorocebus sabaeus (African green monkey) : BAG3 (BAG cochaperone 3)
Heterocephalus glaber (naked mole-rat) : Bag3 (BAG cochaperone 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10119,651,370 - 119,677,819 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl10119,651,380 - 119,677,819 (+)EnsemblGRCh38hg38GRCh38
GRCh3810119,651,380 - 119,677,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710121,410,859 - 121,437,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,400,872 - 121,427,321 (+)NCBINCBI36hg18NCBI36
Build 3410121,400,871 - 121,427,317NCBI
Celera10115,141,910 - 115,168,393 (+)NCBI
Cytogenetic Map10q26.11NCBI
HuRef10115,040,288 - 115,066,931 (+)NCBIHuRef
CHM1_110121,695,782 - 121,722,250 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BAG3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317192
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.