Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IRF7 (interferon regulatory factor 7) Homo sapiens
Symbol: IRF7
Name: interferon regulatory factor 7
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to virus; positive regulation of transcription by RNA polymerase II; and positive regulation of type I interferon production. Localizes to cytosol and nucleoplasm. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IMD39; interferon regulatory factor 7G isoform; interferon regulatory factor-7H; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
Mus musculus (house mouse) : Irf7 (interferon regulatory factor 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf7 (interferon regulatory factor 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf7 (interferon regulatory factor 7)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF7 (interferon regulatory factor 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf7 (interferon regulatory factor 7)
Sus scrofa (pig) : IRF7 (interferon regulatory factor 7)
Chlorocebus sabaeus (African green monkey) : IRF7 (interferon regulatory factor 7)
Heterocephalus glaber (naked mole-rat) : Irf7 (interferon regulatory factor 7)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11612,553 - 615,983 (-)EnsemblGRCh38hg38GRCh38
GRCh3811612,555 - 615,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711612,555 - 615,999 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611602,555 - 605,999 (-)NCBINCBI36hg18NCBI36
Build 3411602,590 - 605,650NCBI
Celera11677,701 - 681,146 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11427,860 - 431,281 (-)NCBIHuRef
CHM1_111611,595 - 615,009 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRF7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317251
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.