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Gene: ADAM12 (ADAM metallopeptidase domain 12) Homo sapiens
Symbol: ADAM12
Name: ADAM metallopeptidase domain 12
Description: Exhibits SH3 domain binding activity. Involved in positive regulation of angiogenesis. Localizes to nucleoplasm and plasma membrane. Implicated in osteoarthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADAM12 overlapping transcript 1 (non-protein coding); ADAM12-OT1; CAR10; disintegrin and metalloproteinase domain-containing protein 12; MCMP; MCMPMltna; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane; MLTN; MLTNA
Mus musculus (house mouse) : Adam12 (a disintegrin and metallopeptidase domain 12 (meltrin alpha))  MGI  Alliance
Rattus norvegicus (Norway rat) : Adam12 (ADAM metallopeptidase domain 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam12 (ADAM metallopeptidase domain 12)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM12 (ADAM metallopeptidase domain 12)
Canis lupus familiaris (dog) : ADAM12 (ADAM metallopeptidase domain 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam12 (ADAM metallopeptidase domain 12)
Sus scrofa (pig) : ADAM12 (ADAM metallopeptidase domain 12)
Chlorocebus sabaeus (African green monkey) : ADAM12 (ADAM metallopeptidase domain 12)
Heterocephalus glaber (naked mole-rat) : Adam12 (ADAM metallopeptidase domain 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10126,012,381 - 126,388,455 (-)EnsemblGRCh38hg38GRCh38
GRCh3810126,012,391 - 126,388,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710127,700,960 - 128,077,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,693,415 - 128,067,055 (-)NCBINCBI36hg18NCBI36
Build 3410127,719,903 - 128,067,014NCBI
Celera10121,478,343 - 121,851,743 (-)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10121,392,073 - 121,764,737 (-)NCBIHuRef
CHM1_110127,982,765 - 128,358,883 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADAM12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317265
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.