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Gene: GARS1 (glycyl-tRNA synthetase 1) Homo sapiens
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Symbol: GARS1
Name: glycyl-tRNA synthetase 1
Description: Exhibits several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Involved in diadenosine tetraphosphate biosynthetic process and tRNA aminoacylation for protein translation. Localizes to the axon and cytosol. Implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AP-4-A synthetase; ap4A synthetase; Charcot-Marie-Tooth neuropathy 2D; Charcot-Marie-Tooth neuropathy, neuronal type, D; CMT2D; diadenosine tetraphosphate synthetase; DSMAV; GARS; glycine tRNA ligase; glycine--tRNA ligase; glycyl-tRNA synthetase; GlyRS; HMN5; SMAD1
Orthologs:
Mus musculus (house mouse) : Gars (glycyl-tRNA synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gars (glycyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gars1 (glycyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GARS1 (glycyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : GARS1 (glycyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gars1 (glycyl-tRNA synthetase 1)
Sus scrofa (pig) : GARS1 (glycyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : GARS1 (glycyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Gars1 (glycyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: GARS1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl730,594,838 - 30,634,033 (+)Ensembl
GRCh38730,594,735 - 30,634,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,634,181 - 30,673,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,600,706 - 30,640,174 (+)NCBINCBI36hg18NCBI36
Build 34730,407,420 - 30,446,884NCBI
Celera730,623,360 - 30,662,827 (+)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,516,030 - 30,555,489 (+)NCBIHuRef
CHM1_1730,634,608 - 30,673,905 (+)NCBICHM1_1
CRA_TCAGchr7v2730,683,834 - 30,723,301 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Genomics

Comparative Map Data
Position Markers
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GARS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317292
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.