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Gene: EXOSC5 (exosome component 5) Homo sapiens
Symbol: EXOSC5
Name: exosome component 5
Description: Predicted to have RNA binding activity. Involved in DNA deamination; defense response to virus; and exonucleolytic catabolism of deadenylated mRNA. Localizes to the exosome (RNase complex); nuclear lumen; and transcriptionally active chromatin; PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH all-trans-retinoic acid; arsane; arsenic atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chronic myelogenous leukemia tumor antigen 28; exosome complex component RRP46; exosome complex exonuclease RRP46; exosome component Rrp46; hRrp46p; MGC111224; MGC12901; p12B; ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p
Mus musculus (house mouse) : Exosc5 (exosome component 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exosc5 (exosome component 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exosc5 (exosome component 5)
Pan paniscus (bonobo/pygmy chimpanzee) : EXOSC5 (exosome component 5)
Canis lupus familiaris (dog) : EXOSC5 (exosome component 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exosc5 (exosome component 5)
Sus scrofa (pig) : EXOSC5 (exosome component 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381941,386,374 - 41,397,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,892,275 - 41,903,289 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,584,115 - 46,595,096 (-)NCBINCBI36hg18NCBI36
Build 341946,584,117 - 46,595,096NCBI
Celera1938,692,141 - 38,703,112 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,324,120 - 38,334,980 (-)NCBIHuRef
CHM1_11941,891,952 - 41,902,933 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EXOSC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317301
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.