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Gene: EXOSC5 (exosome component 5) Homo sapiens
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Symbol: EXOSC5
Name: exosome component 5
Description: Predicted to have RNA binding activity. Involved in DNA deamination; defense response to virus; and exonucleolytic catabolism of deadenylated mRNA. Localizes to the exosome (RNase complex); nuclear lumen; and transcriptionally active chromatin; PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH all-trans-retinoic acid; arsane; arsenic atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chronic myelogenous leukemia tumor antigen 28; exosome complex component RRP46; exosome complex exonuclease RRP46; exosome component Rrp46; hRrp46p; MGC111224; MGC12901; p12B; ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p
Orthologs:
Mus musculus (house mouse) : Exosc5 (exosome component 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exosc5 (exosome component 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exosc5 (exosome component 5)
Pan paniscus (bonobo/pygmy chimpanzee) : EXOSC5 (exosome component 5)
Canis lupus familiaris (dog) : EXOSC5 (exosome component 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exosc5 (exosome component 5)
Sus scrofa (pig) : EXOSC5 (exosome component 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,386,374 - 41,397,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,892,275 - 41,903,289 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,584,115 - 46,595,096 (-)NCBINCBI36hg18NCBI36
Build 341946,584,117 - 46,595,096NCBI
Celera1938,692,141 - 38,703,112 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,324,120 - 38,334,980 (-)NCBIHuRef
CHM1_11941,891,952 - 41,902,933 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EXOSC5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317301
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.