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Gene: NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit) Homo sapiens
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Symbol: NUS1
Name: NUS1 dehydrodolichyl diphosphate synthase subunit
Description: This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C6orf68; CDG1AA; cis-prenyltransferase subunit NgBR; dehydrodolichyl diphosphate syntase complex subunit NUS1; dehydrodolichyl diphosphate synthase complex subunit NUS1; di-trans,poly-cis-decaprenylcistransferase; MGC117249; MGC7199; MGC:7199; MRD55; NgBR; nogo-B receptor; nuclear undecaprenyl pyrophosphate synthase 1 homolog; NUS1, dehydrodolichyl diphosphate synthase subunit; TANGO14; transport and golgi organization 14 homolog
Orthologs:
Related Pseudogenes: NUS1P1   NUS1P2   NUS1P3   NUS1P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,675,460 - 117,710,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376117,996,617 - 118,031,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,103,310 - 118,138,583 (+)NCBINCBI36hg18NCBI36
Build 346118,103,362 - 118,136,441NCBI
Celera6118,739,521 - 118,774,823 (+)NCBI
Cytogenetic Map6q22.1NCBI
HuRef6115,577,729 - 115,612,992 (+)NCBIHuRef
CHM1_16118,260,511 - 118,295,775 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NUS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317328
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.