Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AFF1 (AF4/FMR2 family member 1) Homo sapiens
Symbol: AFF1
Name: AF4/FMR2 family member 1
Description: Predicted to have DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Localizes to the transcription elongation factor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF-4; AF4; AF4-MLL; AF4/FMR2 family, member 1; ALL1-fused gene from chromosome 4 protein; MGC134969; MLL/AF4; MLLT2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 2; PBM1; pre-B-cell monocytic leukemia partner 1; proto-oncogene AF4; translocated to, 2
Mus musculus (house mouse) : Aff1 (AF4/FMR2 family, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aff1 (AF4/FMR2 family, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aff1 (AF4/FMR2 family member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AFF1 (AF4/FMR2 family member 1)
Canis lupus familiaris (dog) : AFF1 (AF4/FMR2 family member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aff1 (AF4/FMR2 family member 1)
Sus scrofa (pig) : AFF1 (AF4/FMR2 family member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38486,934,606 - 87,141,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37487,855,758 - 88,062,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,147,177 - 88,281,215 (+)NCBINCBI36hg18NCBI36
Build 34488,285,318 - 88,419,369NCBI
Celera485,145,587 - 85,351,225 (+)NCBI
Cytogenetic Map4q21.3-q22.1NCBI
HuRef483,600,862 - 83,808,030 (+)NCBIHuRef
CHM1_1487,833,687 - 88,039,595 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AFF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317426
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.