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Gene: AFF1 (AF4/FMR2 family member 1) Homo sapiens
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Symbol: AFF1
Name: AF4/FMR2 family member 1
Description: Predicted to have DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Localizes to the transcription elongation factor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF-4; AF4; AF4-MLL; AF4/FMR2 family, member 1; ALL1-fused gene from chromosome 4 protein; MGC134969; MLL/AF4; MLLT2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 2; PBM1; pre-B-cell monocytic leukemia partner 1; proto-oncogene AF4; translocated to, 2
Orthologs:
Mus musculus (house mouse) : Aff1 (AF4/FMR2 family, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aff1 (AF4/FMR2 family, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aff1 (AF4/FMR2 family member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AFF1 (AF4/FMR2 family member 1)
Canis lupus familiaris (dog) : AFF1 (AF4/FMR2 family member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aff1 (AF4/FMR2 family member 1)
Sus scrofa (pig) : AFF1 (AF4/FMR2 family member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38486,934,606 - 87,141,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37487,855,758 - 88,062,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,147,177 - 88,281,215 (+)NCBINCBI36hg18NCBI36
Build 34488,285,318 - 88,419,369NCBI
Celera485,145,587 - 85,351,225 (+)NCBI
Cytogenetic Map4q21.3-q22.1NCBI
HuRef483,600,862 - 83,808,030 (+)NCBIHuRef
CHM1_1487,833,687 - 88,039,595 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AFF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317426
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.