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Gene: Def6 (differentially expressed in FDCP 6) Mus musculus
Symbol: Def6
Name: differentially expressed in FDCP 6
CRRD ID: 1317435
Description: Localizes to cell-cell junction. Is expressed in several structures, including heart; hemolymphoid system; lung; metanephros; and musculature. Used to study systemic lupus erythematosus. Orthologous to human DEF6 (DEF6 guanine nucleotide exchange factor); INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410003F05Rik; 6430538D02Rik; AV094905; DEF-6; I; Ibp; IRF-4-binding protein; IRF4-binding protein; S; Slat; Slat2; Slat6; SWAP-70-like adapter of T-cells
Homo sapiens (human) : DEF6 (DEF6 guanine nucleotide exchange factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Def6 (DEF6 guanine nucleotide exchange factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Def6 (DEF6 guanine nucleotide exchange factor)
Pan paniscus (bonobo/pygmy chimpanzee) : DEF6 (DEF6 guanine nucleotide exchange factor)
Canis lupus familiaris (dog) : DEF6 (DEF6 guanine nucleotide exchange factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Def6 (DEF6 guanine nucleotide exchange factor)
Sus scrofa (pig) : DEF6 (DEF6 guanine nucleotide exchange factor)
Chlorocebus sabaeus (African green monkey) : DEF6 (DEF6 guanine nucleotide exchange factor)
Heterocephalus glaber (naked mole-rat) : Def6 (DEF6 guanine nucleotide exchange factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391728,426,752 - 28,447,582 (+)NCBI
GRCm381728,207,456 - 28,228,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,207,778 - 28,228,608 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,344,723 - 28,365,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv361727,935,419 - 27,956,188 (+)NCBImm8
Celera1728,761,659 - 28,782,259 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Def6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317435
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.