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Gene: NSD2 (nuclear receptor binding SET domain protein 2) Homo sapiens
Symbol: NSD2
Name: nuclear receptor binding SET domain protein 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and histone methyltransferase activity (H3-K36 specific). Predicted to be involved in regulation of transcription, DNA-templated. Localizes to the nucleoplasm. Implicated in Wolf-Hirschhorn syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ23286; histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; KIAA1090; KMT3F; KMT3G; MGC176638; MMSET; multiple myeloma SET domain containing protein type III; multiple myeloma SET domain-containing protein; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; WHSC1; Wolf-Hirschhorn syndrome candidate 1; wolf-Hirschhorn syndrome candidate 1 protein
Mus musculus (house mouse) : Nsd2 (nuclear receptor binding SET domain protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nsd2 (nuclear receptor binding SET domain protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nsd2 (nuclear receptor binding SET domain protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NSD2 (nuclear receptor binding SET domain protein 2)
Canis lupus familiaris (dog) : NSD2 (nuclear receptor binding SET domain protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nsd2 (nuclear receptor binding SET domain protein 2)
Sus scrofa (pig) : NSD2 (nuclear receptor binding SET domain protein 2)
more info ...
Related Pseudogenes: WHSC1L2P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3841,871,393 - 1,982,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3741,873,123 - 1,983,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,842,921 - 1,953,728 (+)NCBINCBI36hg18NCBI36
Build 3441,908,238 - 1,948,753NCBI
Celera41,806,735 - 1,896,162 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef41,835,879 - 1,925,293 (+)NCBIHuRef
CHM1_141,871,595 - 1,982,597 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NSD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317450
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.