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Gene: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2) Mus musculus
Symbol: Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Description: Predicted to have SUMO binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and spermatogenesis. Localizes to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Is expressed in several structures, including central nervous system; ganglia; and trunk. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; cyclosporin A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D15F32S1h; D7H15F32S1; D7H15F37S1; E3 ubiquitin-protein ligase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2; jdf2; KIAA0393; mKIAA0393; mutant HERC2 isoform; probable E3 ubiquitin-protein ligase HERC2; rjs
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl756,050,196 - 56,231,800 (+)EnsemblGRCm38mm10GRCm38
GRCm38756,050,124 - 56,231,800 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37763,305,525 - 63,487,170 (+)NCBIGRCm37mm9NCBIm37
MGSCv36755,918,272 - 56,099,815 (+)NCBImm8
Celera753,391,067 - 53,570,966 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Herc2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317499
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.