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Gene: PTPN22 (protein tyrosine phosphatase non-receptor type 22) Homo sapiens
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Symbol: PTPN22
Name: protein tyrosine phosphatase non-receptor type 22
Description: Exhibits protein tyrosine phosphatase activity and ubiquitin protein ligase binding activity. Involved in several processes, including regulation of cytokine secretion; regulation of lymphocyte activation; and regulation of signal transduction. Localizes to cytoplasmic side of plasma membrane; nucleus; and perinuclear region of cytoplasm. Implicated in several diseases, including Addison's disease; autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); rheumatoid arthritis (multiple); and vasculitis (multiple). Biomarker of chronic lymphocytic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LYP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 8; PTPN22.5; PTPN22.6; PTPN8; tyrosine-protein phosphatase non-receptor type 22
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh381113,813,811 - 113,871,761 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,375 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,231 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Genomics

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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PTPN22
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317504
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.