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Gene: BCR (BCR activator of RhoGEF and GTPase) Homo sapiens
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Symbol: BCR
Name: BCR activator of RhoGEF and GTPase
Description: Exhibits GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and keratinocyte differentiation. Localizes to the protein-containing complex. Implicated in chronic myeloid leukemia; leukemia; and precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALL; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; CML; D22S11; D22S662; FGFR1/BCR chimera protein; FLJ16453; PHL; renal carcinoma antigen NY-REN-26
Orthologs:
Mus musculus (house mouse) : Bcr (BCR activator of RhoGEF and GTPase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcr (BCR activator of RhoGEF and GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcr (BCR activator of RhoGEF and GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : BCR (BCR activator of RhoGEF and GTPase)
Canis lupus familiaris (dog) : BCR (BCR activator of RhoGEF and GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcr (BCR activator of RhoGEF and GTPase)
Sus scrofa (pig) : BCR (BCR activator of RhoGEF and GTPase)
more info ...
Related Pseudogenes: BCRP1   BCRP2   BCRP3   BCRP4   BCRP5   BCRP6   BCRP7   BCRP8   BCRP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,180,509 - 23,318,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372223,522,402 - 23,660,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,852,552 - 21,990,224 (+)NCBINCBI36hg18NCBI36
Build 342221,847,105 - 21,982,690NCBI
Celera227,337,083 - 7,474,738 (+)NCBI
Cytogenetic Map22q11.23ENTREZGENE
HuRef226,461,675 - 6,627,574 (+)NCBIHuRef
CHM1_12223,534,806 - 23,672,427 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BCR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317506
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.