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Gene: TIGAR (TP53 induced glycolysis regulatory phosphatase) Homo sapiens
Symbol: TIGAR
Name: TP53 induced glycolysis regulatory phosphatase
Description: Exhibits bisphosphoglycerate 2-phosphatase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including fructose 1,6-bisphosphate metabolic process; fructose 2,6-bisphosphate metabolic process; and regulation of cellular carbohydrate metabolic process. Localizes to the cytosol; mitochondrial outer membrane; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C12orf5; FR2BP; fructose-2,6-bisphosphatase TIGAR; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase; transactivated by NS3TP2 protein
Mus musculus (house mouse) : Tigar (Trp53 induced glycolysis regulatory phosphatase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tigar (TP53 induced glycolysis regulatory phosphatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tigar (TP53 induced glycolysis regulatory phosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : TIGAR (TP53 induced glycolysis regulatory phosphatase)
Canis lupus familiaris (dog) : TIGAR (TP53 induced glycolysis regulatory phosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tigar (TP53 induced glycolysis regulatory phosphatase)
Sus scrofa (pig) : TIGAR (TP53 induced glycolysis regulatory phosphatase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38124,321,213 - 4,360,028 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37124,430,359 - 4,469,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,300,620 - 4,339,455 (+)NCBINCBI36hg18NCBI36
Build 34124,300,631 - 4,332,599NCBI
Celera126,052,425 - 6,091,264 (+)NCBI
Cytogenetic Map12p13.32NCBI
HuRef124,287,018 - 4,325,825 (+)NCBIHuRef
CHM1_1124,429,992 - 4,468,805 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TIGAR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317526
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.