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Gene: RNF8 (ring finger protein 8) Homo sapiens
Symbol: RNF8
Name: ring finger protein 8
CRRD ID: 1317571
Description: Exhibits several functions, including protein homodimerization activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of nucleobase-containing compound metabolic process; and response to ionizing radiation. Localizes to several cellular components, including nucleoplasm; site of double-strand break; and ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C3HC4-type zinc finger protein; E3 ubiquitin-protein ligase RNF8; FLJ12013; hRNF8; KIAA0646; ring finger protein (C3HC4 type) 8; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8; UBC13/UEV-interacting ring finger protein
Mus musculus (house mouse) : Rnf8 (ring finger protein 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf8 (ring finger protein 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf8 (ring finger protein 8)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF8 (ring finger protein 8)
Canis lupus familiaris (dog) : RNF8 (ring finger protein 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf8 (ring finger protein 8)
Sus scrofa (pig) : RNF8 (ring finger protein 8)
Chlorocebus sabaeus (African green monkey) : RNF8 (ring finger protein 8)
Heterocephalus glaber (naked mole-rat) : Rnf8 (ring finger protein 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl637,353,979 - 37,394,734 (+)EnsemblGRCh38hg38GRCh38
GRCh38637,353,983 - 37,394,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37637,321,748 - 37,362,514 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,429,726 - 37,470,492 (+)NCBINCBI36hg18NCBI36
Build 34637,429,768 - 37,470,491NCBI
Celera638,876,721 - 38,917,497 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef637,040,684 - 37,081,344 (+)NCBIHuRef
CHM1_1637,323,524 - 37,364,290 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNF8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317571
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.