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Gene: VPS11 (VPS11 core subunit of CORVET and HOPS complexes) Homo sapiens
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Symbol: VPS11
Name: VPS11 core subunit of CORVET and HOPS complexes
Description: Exhibits protein domain specific binding activity and syntaxin binding activity. Involved in several processes, including endosomal vesicle fusion; endosome to lysosome transport; and positive regulation of early endosome to late endosome transport. Localizes to the HOPS complex; cytoplasmic vesicle; and lysosome. Colocalizes with the early endosome. Implicated in hypomyelinating leukodystrophy 12.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: END1; HLD12; hVPS11; PEP5; RING finger protein 108; RNF108; vacuolar protein sorting 11 homolog; vacuolar protein sorting protein 11; vacuolar protein sorting-associated protein 11 homolog; VPS11 CORVET/HOPS core subunit; VPS11, CORVET/HOPS core subunit
Orthologs:
Mus musculus (house mouse) : Vps11 (VPS11, CORVET/HOPS core subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vps11 (VPS11 core subunit of CORVET and HOPS complexes)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vps11 (VPS11 core subunit of CORVET and HOPS complexes)
Pan paniscus (bonobo/pygmy chimpanzee) : VPS11 (VPS11 core subunit of CORVET and HOPS complexes)
Canis lupus familiaris (dog) : VPS11 (VPS11 core subunit of CORVET and HOPS complexes)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vps11 (VPS11 core subunit of CORVET and HOPS complexes)
Sus scrofa (pig) : VPS11 (VPS11 core subunit of CORVET and HOPS complexes)
Chlorocebus sabaeus (African green monkey) : VPS11 (VPS11 core subunit of CORVET and HOPS complexes)
Heterocephalus glaber (naked mole-rat) : Vps11 (VPS11 core subunit of CORVET and HOPS complexes)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl11119,067,692 - 119,081,978 (+)EnsemblGRCh38hg38GRCh38
GRCh3811119,067,792 - 119,081,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,938,493 - 118,952,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,443,703 - 118,457,898 (+)NCBINCBI36hg18NCBI36
Build 3411118,443,702 - 118,457,884NCBI
Celera11116,096,175 - 116,110,109 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,878,034 - 114,892,141 (+)NCBIHuRef
CHM1_111118,824,741 - 118,838,977 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

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Nomenclature History
 
More on VPS11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317575
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.