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Gene: TP53BP1 (tumor protein p53 binding protein 1) Homo sapiens
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Symbol: TP53BP1
Name: tumor protein p53 binding protein 1
Description: Exhibits several functions, including RNA polymerase II activating transcription factor binding activity; histone binding activity; and p53 binding activity. Involved in double-strand break repair via nonhomologous end joining; protein homooligomerization; and regulation of nucleobase-containing compound metabolic process. Localizes to the cytoplasm; nuclear body; and site of double-strand break. Colocalizes with the chromosome, telomeric region. Biomarker of pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 53BP1; FLJ41424; MGC138366; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Orthologs:
Mus musculus (house mouse) : Trp53bp1 (transformation related protein 53 binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp53bp1 (tumor protein p53 binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53bp1 (tumor protein p53 binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53BP1 (tumor protein p53 binding protein 1)
Canis lupus familiaris (dog) : TP53BP1 (tumor protein p53 binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53bp1 (tumor protein p53 binding protein 1)
Sus scrofa (pig) : TP53BP1 (tumor protein p53 binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,403,061 - 43,510,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371543,695,262 - 43,802,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,486,699 - 41,590,028 (-)NCBINCBI36hg18NCBI36
Build 341541,486,698 - 41,590,028NCBI
Celera1520,470,061 - 20,573,379 (-)NCBI
Cytogenetic Map15q15.3NCBI
HuRef1520,547,443 - 20,650,644 (-)NCBIHuRef
CHM1_11543,818,081 - 43,921,400 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TP53BP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317577
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.