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Gene: TP53BP1 (tumor protein p53 binding protein 1) Homo sapiens
Symbol: TP53BP1
Name: tumor protein p53 binding protein 1
Description: Exhibits several functions, including RNA polymerase II activating transcription factor binding activity; histone binding activity; and p53 binding activity. Involved in double-strand break repair via nonhomologous end joining; protein homooligomerization; and regulation of nucleobase-containing compound metabolic process. Localizes to the cytoplasm; nuclear body; and site of double-strand break. Colocalizes with the chromosome, telomeric region. Biomarker of pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 53BP1; FLJ41424; MGC138366; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Mus musculus (house mouse) : Trp53bp1 (transformation related protein 53 binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp53bp1 (tumor protein p53 binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53bp1 (tumor protein p53 binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53BP1 (tumor protein p53 binding protein 1)
Canis lupus familiaris (dog) : TP53BP1 (tumor protein p53 binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53bp1 (tumor protein p53 binding protein 1)
Sus scrofa (pig) : TP53BP1 (tumor protein p53 binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381543,403,061 - 43,510,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371543,695,262 - 43,802,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,486,699 - 41,590,028 (-)NCBINCBI36hg18NCBI36
Build 341541,486,698 - 41,590,028NCBI
Celera1520,470,061 - 20,573,379 (-)NCBI
Cytogenetic Map15q15.3NCBI
HuRef1520,547,443 - 20,650,644 (-)NCBIHuRef
CHM1_11543,818,081 - 43,921,400 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TP53BP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317577
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.