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Gene: Trp53bp1 (transformation related protein 53 binding protein 1) Mus musculus
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Symbol: Trp53bp1
Name: transformation related protein 53 binding protein 1
Description: Exhibits damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Localizes to the DNA repair complex; chromosome; and nuclear body. Predicted to colocalize with the chromosome, telomeric region. Is expressed in ileum; lung; metanephros; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 53BP1; m53BP1; MGC100303; murine p53-binding protein; p53-binding protein 1; p53BP1; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding-protein 1; tumor suppressor p53-binding protein 1
Orthologs:
Homo sapiens (human) : TP53BP1 (tumor protein p53 binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tp53bp1 (tumor protein p53 binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53bp1 (tumor protein p53 binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53BP1 (tumor protein p53 binding protein 1)
Canis lupus familiaris (dog) : TP53BP1 (tumor protein p53 binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53bp1 (tumor protein p53 binding protein 1)
Sus scrofa (pig) : TP53BP1 (tumor protein p53 binding protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382121,194,835 - 121,296,354 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372121,022,463 - 121,097,122 (-)NCBIGRCm37mm9NCBIm37
MGSCv362120,889,692 - 120,962,561 (-)NCBImm8
Celera2122,346,827 - 122,423,056 (-)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Trp53bp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317578
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.