Gene: IRF4 (interferon regulatory factor 4) Homo sapiens
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Symbol: IRF4
Name: interferon regulatory factor 4
Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRF-4; LSIRF; lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; SHEP8
Orthologs:
Mus musculus (house mouse) : Irf4 (interferon regulatory factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf4 (interferon regulatory factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf4 (interferon regulatory factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF4 (interferon regulatory factor 4)
Canis lupus familiaris (dog) : IRF4 (interferon regulatory factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf4 (interferon regulatory factor 4)
Sus scrofa (pig) : IRF4 (interferon regulatory factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386391,739 - 411,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376391,739 - 411,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366336,760 - 356,193 (+)NCBINCBI36hg18NCBI36
Build 346336,759 - 356,193NCBI
Celera61,620,599 - 1,639,926 (+)NCBI
Cytogenetic Map6p25.3NCBI
HuRef6264,308 - 284,078 (+)NCBIHuRef
CHM1_16393,650 - 413,301 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on IRF4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317594
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-05-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.