Gene: IRF4 (interferon regulatory factor 4) Homo sapiens
Symbol: IRF4
Name: interferon regulatory factor 4
Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRF-4; LSIRF; lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; SHEP8
Mus musculus (house mouse) : Irf4 (interferon regulatory factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf4 (interferon regulatory factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf4 (interferon regulatory factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF4 (interferon regulatory factor 4)
Canis lupus familiaris (dog) : IRF4 (interferon regulatory factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf4 (interferon regulatory factor 4)
Sus scrofa (pig) : IRF4 (interferon regulatory factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386391,739 - 411,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376391,739 - 411,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366336,760 - 356,193 (+)NCBINCBI36hg18NCBI36
Build 346336,759 - 356,193NCBI
Celera61,620,599 - 1,639,926 (+)NCBI
Cytogenetic Map6p25.3NCBI
HuRef6264,308 - 284,078 (+)NCBIHuRef
CHM1_16393,650 - 413,301 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317594
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-05-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.