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Gene: GPS2 (G protein pathway suppressor 2) Homo sapiens
Symbol: GPS2
Name: G protein pathway suppressor 2
CRRD ID: 1317604
Description: Exhibits cyclin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of JNK cascade; positive regulation of cholesterol efflux; and regulation of transcription by RNA polymerase II. Localizes to several cellular components, including cytosol; mitochondrion; and transcription repressor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMF-1; GPS-2; MGC104294; MGC119287; MGC119288; MGC119289
Mus musculus (house mouse) : Gps2 (G protein pathway suppressor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gps2 (G protein pathway suppressor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gps2 (G protein pathway suppressor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GPS2 (G protein pathway suppressor 2)
Canis lupus familiaris (dog) : GPS2 (G protein pathway suppressor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gps2 (G protein pathway suppressor 2)
Sus scrofa (pig) : GPS2 (G protein pathway suppressor 2)
Chlorocebus sabaeus (African green monkey) : GPS2 (G protein pathway suppressor 2)
Heterocephalus glaber (naked mole-rat) : Gps2 (G protein pathway suppressor 2)
more info ...
Related Pseudogenes: GPS2P1   GPS2P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl177,311,324 - 7,315,564 (-)EnsemblGRCh38hg38GRCh38
GRCh38177,312,661 - 7,315,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,215,978 - 7,218,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,156,702 - 7,159,382 (-)NCBINCBI36hg18NCBI36
Build 34177,156,701 - 7,159,382NCBI
Celera177,241,919 - 7,244,599 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,110,027 - 7,112,707 (-)NCBIHuRef
CHM1_1177,224,746 - 7,227,426 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317604
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.