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Gene: Actn2 (actinin alpha 2) Mus musculus
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Symbol: Actn2
Name: actinin alpha 2
CRRD ID: 1317672
Description: Exhibits several functions, including LIM domain binding activity; ion channel binding activity; and thyroid hormone receptor coactivator activity. Involved in several processes, including cardiac muscle cell development; positive regulation of transport; and protein localization to plasma membrane. Localizes to Z disc. Predicted to colocalize with cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including alimentary system; heart; limb; musculature; and trunk somite. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110008F24Rik; alpha-actinin skeletal muscle; alpha-actinin-2; F-actin cross-linking protein; MGC107582
Orthologs:
Homo sapiens (human) : ACTN2 (actinin alpha 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Actn2 (actinin alpha 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn2 (actinin alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN2 (actinin alpha 2)
Canis lupus familiaris (dog) : ACTN2 (actinin alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn2 (actinin alpha 2)
Sus scrofa (pig) : ACTN2 (actinin alpha 2)
Chlorocebus sabaeus (African green monkey) : ACTN2 (actinin alpha 2)
Heterocephalus glaber (naked mole-rat) : Actn2 (actinin alpha 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBI
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBImm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Actn2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317672
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.