Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Actn2 (actinin alpha 2) Mus musculus
Symbol: Actn2
Name: actinin alpha 2
CRRD ID: 1317672
Description: Exhibits several functions, including LIM domain binding activity; ion channel binding activity; and thyroid hormone receptor coactivator activity. Involved in several processes, including cardiac muscle cell development; positive regulation of transport; and protein localization to plasma membrane. Localizes to Z disc. Predicted to colocalize with cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including alimentary system; heart; limb; musculature; and trunk somite. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110008F24Rik; alpha-actinin skeletal muscle; alpha-actinin-2; F-actin cross-linking protein; MGC107582
Homo sapiens (human) : ACTN2 (actinin alpha 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Actn2 (actinin alpha 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn2 (actinin alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN2 (actinin alpha 2)
Canis lupus familiaris (dog) : ACTN2 (actinin alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn2 (actinin alpha 2)
Sus scrofa (pig) : ACTN2 (actinin alpha 2)
Chlorocebus sabaeus (African green monkey) : ACTN2 (actinin alpha 2)
Heterocephalus glaber (naked mole-rat) : Actn2 (actinin alpha 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391312,284,312 - 12,355,613 (-)NCBI
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBImm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Actn2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317672
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.