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Gene: CUL1 (cullin 1) Homo sapiens
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Symbol: CUL1
Name: cullin 1
Description: Predicted to have ubiquitin protein ligase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Localizes to the Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex; PARTICIPATES IN neddylation pathway; Notch signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH aflatoxin B1; all-trans-retinoic acid; antirheumatic drug.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CUL-1; cullin-1; MGC149834; MGC149835
Orthologs:
Mus musculus (house mouse) : Cul1 (cullin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cul1 (cullin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cul1 (cullin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CUL1 (cullin 1)
Canis lupus familiaris (dog) : CUL1 (cullin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cul1 (cullin 1)
Sus scrofa (pig) : CUL1 (cullin 1)
more info ...
Related Pseudogenes: CUL1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7148,697,914 - 148,801,110 (+)Ensembl
GRCh387148,697,756 - 148,801,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,395,631 - 148,498,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,026,866 - 148,129,135 (+)NCBINCBI36hg18NCBI36
Build 347147,833,580 - 147,935,849NCBI
Celera7143,066,358 - 143,168,625 (+)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,474,925 - 142,577,198 (+)NCBIHuRef
CHM1_17148,404,339 - 148,506,599 (+)NCBICHM1_1
CRA_TCAGchr7v27147,733,888 - 147,836,155 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CUL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317768
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.