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Gene: TCF7L2 (transcription factor 7 like 2) Homo sapiens
Symbol: TCF7L2
Name: transcription factor 7 like 2
Description: Exhibits several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of protein transport; regulation of cellular macromolecule biosynthetic process; and regulation of signal transduction. Localizes to nucleus and protein-DNA complex. Implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HMG box transcription factor 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-4; TCF4; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box)
Mus musculus (house mouse) : Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tcf7l2 (transcription factor 7 like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf7l2 (transcription factor 7 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF7L2 (transcription factor 7 like 2)
Canis lupus familiaris (dog) : TCF7L2 (transcription factor 7 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf7l2 (transcription factor 7 like 2)
Sus scrofa (pig) : TCF7L2 (transcription factor 7 like 2)
Chlorocebus sabaeus (African green monkey) : TCF7L2 (transcription factor 7 like 2)
Heterocephalus glaber (naked mole-rat) : Tcf7l2 (transcription factor 7 like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10112,950,247 - 113,167,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,950,247 - 113,167,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,709,978 - 114,927,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,700,201 - 114,916,063 (+)NCBINCBI36hg18NCBI36
Build 3410114,700,200 - 114,916,058NCBI
Celera10108,437,726 - 108,655,178 (+)NCBI
Cytogenetic Map10q25.2-q25.3NCBI
HuRef10108,337,509 - 108,554,907 (+)NCBIHuRef
CHM1_110114,992,047 - 115,209,474 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TCF7L2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317786
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.