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Gene: Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box) Mus musculus
Symbol: Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including animal organ development; regulation of cellular biosynthetic process; and regulation of insulin secretion. Localizes to catenin-TCF7L2 complex; cytosol; and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; pancreatic cancer pathway; acute myeloid leukemia pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HMG box transcription factor 4; HMG box transcription factor TCF7L2; mTCF-4; mTcf-4B; mTcf-4E; T-cell factor 4; T-cell-specific transcription factor 4; Tcf-4; Tcf4; TCF4B; TCF4E; transcription factor 7-like 2; transcription factor 7-like 2, T-cell specific, HMG-box
Homo sapiens (human) : TCF7L2 (transcription factor 7 like 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tcf7l2 (transcription factor 7 like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf7l2 (transcription factor 7 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF7L2 (transcription factor 7 like 2)
Canis lupus familiaris (dog) : TCF7L2 (transcription factor 7 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf7l2 (transcription factor 7 like 2)
Sus scrofa (pig) : TCF7L2 (transcription factor 7 like 2)
Chlorocebus sabaeus (African green monkey) : TCF7L2 (transcription factor 7 like 2)
Heterocephalus glaber (naked mole-rat) : Tcf7l2 (transcription factor 7 like 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1955,741,820 - 55,933,654 (+)EnsemblGRCm38mm10GRCm38
GRCm381955,741,797 - 55,933,659 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371955,816,300 - 56,008,145 (+)NCBIGRCm37mm9NCBIm37
MGSCv361955,795,518 - 55,986,492 (+)NCBImm8
Celera1957,933,629 - 58,125,906 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tcf7l2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317787
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.