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Gene: CUL3 (cullin 3) Homo sapiens
Symbol: CUL3
Name: cullin 3
Description: Exhibits several functions, including Notch binding activity; POZ domain binding activity; and ubiquitin protein ligase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including COPII vesicle coating; cellular protein metabolic process; and positive regulation of cell cycle process. Localizes to several cellular components, including Cul3-RING ubiquitin ligase complex; microtubule cytoskeleton; and sperm flagellum. Implicated in pseudohypoaldosteronism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CUL-3; cullin-3; FLJ25665; PHA2E
Mus musculus (house mouse) : Cul3 (cullin 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cul3 (cullin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cul3 (cullin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CUL3 (cullin 3)
Canis lupus familiaris (dog) : CUL3 (cullin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cul3 (cullin 3)
Sus scrofa (pig) : CUL3 (cullin 3)
Chlorocebus sabaeus (African green monkey) : CUL3 (cullin 3)
Heterocephalus glaber (naked mole-rat) : Cul3 (cullin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2224,470,150 - 224,585,397 (-)EnsemblGRCh38hg38GRCh38
GRCh382224,470,150 - 224,585,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372225,334,867 - 225,450,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBINCBI36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBI
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CUL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317824
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.