Guca1b (guanylate cyclase activator 1B) - Chinchilla Research Resource Database
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Gene: Guca1b (guanylate cyclase activator 1B) Mus musculus
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Symbol: Guca1b
Name: guanylate cyclase activator 1B
CRRD ID: 1317827
Description: Exhibits calcium sensitive guanylate cyclase activator activity. Involved in phototransduction; regulation of guanylate cyclase activity; and visual perception. Predicted to localize to cone photoreceptor outer segment and photoreceptor inner segment. Is expressed in retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 48. Orthologous to human GUCA1B (guanylate cyclase activator 1B); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC018258; GCA; GCAP 2; GCAP2; GCAP2 (retina); guanylyl cyclase-activating protein 2; MGC36472
Orthologs:
Homo sapiens (human) : GUCA1B (guanylate cyclase activator 1B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Guca1b (guanylate cyclase activator 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Guca1b (guanylate cyclase activator 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCA1B (guanylate cyclase activator 1B)
Canis lupus familiaris (dog) : GUCA1B (guanylate cyclase activator 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Guca1b (guanylate cyclase activator 1B)
Sus scrofa (pig) : GUCA1B (guanylate cyclase activator 1B)
Chlorocebus sabaeus (African green monkey) : GUCA1B (guanylate cyclase activator 1B)
Heterocephalus glaber (naked mole-rat) : Guca1b (guanylate cyclase activator 1B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,692,526 - 47,703,892 (+)NCBI
GRCm381747,384,694 - 47,392,967 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,385,393 - 47,392,967 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,522,342 - 47,529,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv361746,848,584 - 46,856,158 (+)NCBImm8
Celera1750,820,210 - 50,827,774 (+)NCBICelera
Cytogenetic Map17CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9579466   PMID:9888789   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11493703   PMID:11927539   PMID:12367508   PMID:12477932   PMID:12596933  
PMID:12732716   PMID:12975449   PMID:15173221   PMID:15226823   PMID:15336959   PMID:15489334   PMID:16110338   PMID:16141072   PMID:16141073   PMID:18425122   PMID:18723510   PMID:19332500  
PMID:19901021   PMID:20403975   PMID:20463219   PMID:20684533   PMID:21123569   PMID:21598940   PMID:21632921   PMID:21677750   PMID:22451436   PMID:22623665   PMID:22678504   PMID:22912773  
PMID:23082185   PMID:23472098   PMID:24214653   PMID:24557353   PMID:25058152   PMID:25616661   PMID:25673692   PMID:25757744   PMID:27471269   PMID:28186874   PMID:29440533   PMID:29440717  
PMID:29549122   PMID:30367097   PMID:30459230   PMID:30718640   PMID:31346032   PMID:32098917  


Genomics

Comparative Map Data
Guca1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,692,526 - 47,703,892 (+)NCBI
GRCm381747,384,694 - 47,392,967 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,385,393 - 47,392,967 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,522,342 - 47,529,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv361746,848,584 - 46,856,158 (+)NCBImm8
Celera1750,820,210 - 50,827,774 (+)NCBICelera
Cytogenetic Map17CNCBI
GUCA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl642,183,284 - 42,194,956 (-)EnsemblGRCh38hg38GRCh38
GRCh38642,183,284 - 42,194,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37642,151,022 - 42,162,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36642,259,000 - 42,270,672 (-)NCBINCBI36hg18NCBI36
Build 34642,260,530 - 42,270,536NCBI
Celera643,703,483 - 43,715,150 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef641,869,069 - 41,880,681 (-)NCBIHuRef
CHM1_1642,153,499 - 42,165,156 (-)NCBICHM1_1
Guca1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0915,621,083 - 15,629,017 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,621,083 - 15,629,017 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,542,073 - 14,550,007 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,058,038 - 9,065,831 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.199,056,336 - 9,063,113 (-)NCBI
Celera911,350,129 - 11,357,890 (-)NCBICelera
Cytogenetic Map9q12NCBI
Guca1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,382,299 - 8,390,946 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,384,692 - 8,390,946 (-)NCBIChiLan1.0ChiLan1.0
GUCA1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1643,072,469 - 43,083,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,072,469 - 43,083,838 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0641,771,537 - 41,783,364 (-)NCBIMhudiblu_PPA_v0panPan3
GUCA1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1210,797,921 - 10,834,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11210,796,961 - 10,806,796 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Guca1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647617,679,505 - 17,688,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,297,905 - 37,310,170 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,297,901 - 37,311,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,760,583 - 42,767,565 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GUCA1B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1729,957,508 - 29,967,922 (+)Ensembl
ChlSab1.11729,957,206 - 29,969,294 (+)NCBI
Guca1b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,083,523 - 17,087,010 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4274029451432094Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174340000052800000Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174470566549059374Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
35673315Ari1_mantibody response to influenza 1, day 7, IgG2a+IgG2c (mouse)174700000054400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:582
Count of miRNA genes:384
Interacting mature miRNAs:413
Transcripts:ENSMUST00000024774, ENSMUST00000145462
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_146079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000024774   ⟹   ENSMUSP00000024774
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,385,393 - 47,392,967 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145462   ⟹   ENSMUSP00000126799
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,385,404 - 47,392,093 (+)Ensembl
RefSeq Acc Id: NM_146079   ⟹   NP_666191
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391747,696,318 - 47,703,892 (+)NCBI
GRCm381747,385,393 - 47,392,967 (+)NCBI
MGSCv371747,522,342 - 47,529,916 (+)RGD
Celera1750,820,210 - 50,827,774 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036160257   ⟹   XP_036016150
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391747,692,526 - 47,703,892 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_666191   ⟸   NM_146079
- UniProtKB: Q8VBV8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126799   ⟸   ENSMUST00000145462
RefSeq Acc Id: ENSMUSP00000024774   ⟸   ENSMUST00000024774
RefSeq Acc Id: XP_036016150   ⟸   XM_036160257
- Peptide Label: isoform X1
Protein Domains
EF-hand

Promoters
RGD ID:13676280
Promoter ID:EPDNEW_M22289
Type:initiation region
Name:Guca1b_1
Description:Mus musculus guanylate cyclase activator 1B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381747,385,400 - 47,385,460EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1194489 AgrOrtholog
Ensembl Genes ENSMUSG00000023979 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000116266 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000024774 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126799 UniProtKB/TrEMBL
  ENSMUSP00000155668 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024774 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000145462 UniProtKB/TrEMBL
  ENSMUST00000229925 UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCAP-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recoverin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:107477 UniProtKB/Swiss-Prot
MGD MGI:1194489 ENTREZGENE
NCBI Gene 107477 ENTREZGENE
PANTHER PTHR23055 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23055:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Guca1b PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.59151 ENTREZGENE
UniProt E9PWU1_MOUSE UniProtKB/TrEMBL
  GUC1B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE