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Gene: FRS2 (fibroblast growth factor receptor substrate 2) Homo sapiens
Symbol: FRS2
Name: fibroblast growth factor receptor substrate 2
Description: Exhibits fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in fibroblast growth factor receptor signaling pathway and negative regulation of cardiac muscle cell differentiation. Localizes to the cell-cell adherens junction. Biomarker of renal cell carcinoma; PARTICIPATES IN fibroblast growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; antirheumatic drug; carbamazepine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; suc1-associated neurotrophic factor target 1
Mus musculus (house mouse) : Frs2 (fibroblast growth factor receptor substrate 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Frs2 (fibroblast growth factor receptor substrate 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frs2 (fibroblast growth factor receptor substrate 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FRS2 (fibroblast growth factor receptor substrate 2)
Canis lupus familiaris (dog) : FRS2 (fibroblast growth factor receptor substrate 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frs2 (fibroblast growth factor receptor substrate 2)
Sus scrofa (pig) : FRS2 (fibroblast growth factor receptor substrate 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381269,470,371 - 69,579,793 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371269,864,129 - 69,973,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,150,396 - 68,259,829 (+)NCBINCBI36hg18NCBI36
Build 341268,150,452 - 68,255,011NCBI
Celera1269,527,782 - 69,637,211 (+)NCBI
Cytogenetic Map12q15NCBI
HuRef1266,913,617 - 67,023,032 (+)NCBIHuRef
CHM1_11269,832,586 - 69,941,996 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FRS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317842
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.